64461-82-1
64461-82-1 structure
- Name: Tizanidine hydrochloride
- Chemical Name: Tizanidine hydrochloride
- CAS Number: 64461-82-1
- Molecular Formula: C9H9Cl2N5S
- Molecular Weight: 290.17200
- Catalog: API Digestive system medication Gastrointestinal expectorant
- Create Date: 2018-09-29 09:08:35
- Modify Date: 2026-07-01 22:07:02
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Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Target: α2-adrenergic receptorTizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment.
| Name | Tizanidine hydrochloride |
|---|---|
| Synonyms |
Enchinin
Tizanidine hydrochloride, 10 mM in DMSO Gibonz 1,3-benzothiadiazol-4-amine,5-chloro-n-(4,5-dihydro-1h-imidazol-2-yl)-mono 5-Chloro-4-[(4,5-dihydro-1H-imidazol-2-yl)amino]-2,1,3-benzothiadiazole Hydrochloride Astonelin 5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazolehydrochloride Tizanidine Hydrochloride Tizanidine impurity B CRS Tizanidine HCl (BRN 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine,hydrochloride Tizanidine HCl - Bio-X TIZANIDINE HCL Tizanidinechlorhydrate 2-[2-({[5-(diethylamino)pentan-2-yl]amino}methyl)-1-azabicyclo[2.2.2]oct-3-yl]ethanol Zanpeak TizanidineHydrochloride(Patent) Tizanidine hydrochloride salt AB-021 5-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOL-4-AMINE HYDROCHLORIDE MFCD00798231 Tizanidine hydrochloride CRS Unii-B53E3nmy5c SIRDALUD TERNELIN DS-103-282 5-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-2,1,3-BENZOTHIADIAZOLE-4-AMINE HYDROCHLORIDE 2,1,3-Benzothiadiazol-4-aMine,5-chloro-N-(4,5-dihydro-1H-iMidazol-2-yl)-, hydrochloride (1:1) Tizanidine hydrochloride //BP Tizanidine hydrochloride 100 μg/mL in Acetonitrile Tizanidine HydrochlorideQ: What is Tizanidine Hydrochloride Q: What is the CAS Number of Tizanidine Hydrochloride Q: What is the storage condition of Tizanidine Hydrochloride Q: What e the applications of Tizanidine Hydrochloride 5-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine, Hydrochloride, AB-021, DS-103-282, Sirdalud, Ternelin, Zanaflex ZANAFLEX 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride |
| Description | Tizanidine hydrochloride is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.Target: α2-adrenergic receptorTizanidine is a drug that is used as a muscle relaxant. It is a centrally acting α2 adrenergic agonist. It is used to treat the spasms, cramping, and tightness of muscles caused by medical problems such as multiple sclerosis, ALS, spastic diplegia, back pain, or certain other injuries to the spine or central nervous system. It is also prescribed off-label for migraine headaches, as a sleep aid, and as an anticonvulsant. It is also prescribed for some symptoms of fibromyalgia.Tizanidine has been found to be as effective as other antispasmodic drugs and has superior tolerability to that of baclofen and diazepam. Tizanidine can be very strong even at the 2 mg dose and may cause hypotension, so caution is advised when it is used in patients who have a history of orthostatic hypotension, or when switching from gel cap to tablet form and vice versa. Tizanidine can occasionally cause liver damage, generally the hepatocellular type. Clinical trials show that up to 5% of patients treated with tizanidine had elevated liver function test values, though symptoms disappeared upon withdrawal of the drug. Care should be used when first beginning treatment with tizanidine with regular liver tests for the first 6 months of treatment. |
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| Related Catalog | |
| References |
| Boiling Point | 391.2ºC at 760 mmHg |
|---|---|
| Melting Point | 280 °C |
| Molecular Formula | C9H9Cl2N5S |
| Molecular Weight | 290.17200 |
| Flash Point | 190.4ºC |
| Exact Mass | 288.99600 |
| PSA | 90.44000 |
| LogP | 2.35520 |
| Storage condition | Desiccate at RT |
| Water Solubility | H2O: ~29 mg/mL |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H319-H335 |
| Precautionary Statements | P301 + P312 + P330-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R22;R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DK9910000 |
| HS Code | 2934300000 |
| HS Code | 2934300000 |
|---|---|
| Summary | 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |