Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MIRA-1
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: NSC 19630
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: NSC 19630
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (2,5-dioxopyrrol-1-yl)methyl propanoate
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

72835-26-8

72835-26-8 structure

72835-26-8 structure

Name: MIRA-1
Chemical Name: (2,5-dioxopyrrol-1-yl)methyl propanoate
CAS Number: 72835-26-8
Molecular Formula: C₈H₉NO₄
Molecular Weight: 183.16
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-12-26 20:18:22
Modify Date: 2024-01-12 11:29:44
MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1].

Name	(2,5-dioxopyrrol-1-yl)methyl propanoate
Synonyms	MIRA-1 N-propionyloxymethyl-maleimide N-Propionyloxymethyl-maleinimid NSC 19630

Description	MIRA-1 is a maleimide analogue. MIRA-1 can induce apoptosis in mutant p53 cells via restoration of p53-dependent transcriptional transactivation. MIRA-1 has anticancer activity[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53
Target	IC50: 10 μM (Saos-2 His273)[1]
In Vitro	MIRA-1 suppresses growth of Saos-2-His273 cells expressing mutant p53[1]. MIRA-1 (25 μM; 48 hours) inhibits cell growth in a mutant p53-dependent manner[1]. MIRA-1 (5 μM; 14 days) dramatically reduces the number of colonies formed by His273-expressing Saos-2 cells, but is much less efficient in inhibiting p53-null Saos-2 cells[1]. MIRA-1 (10 μM; 48 hours) causes a substantial increase in the fraction of Saos-2 and Saos-2-His273 cells with a sub-G1 DNA content in the presence of mutant p53[1]. MIRA-1 (5 and 10 μM; 24 hours) induces EGFP expression, MDM2 and Bax in SKOV-His175 cells[1]. Cell Proliferation Assay Cell Line: Saos-2-His273, H1299-His175, SKOV-His175 and SKOV-His273[1] Concentration: 25 μM Incubation Time: 48 hours Result: Inhibited cell growth in a mutant p53-dependent manner, with survival rate of 18.5~39% in no doxycycline and 71.5~87.5% in doxycycline. Apoptosis Analysis Cell Line: Saos-2 and Saos-2-His273 cells[1] Concentration: 10 μM Incubation Time: 48 hours Result: Caused a substantial increase in the fraction of cells with a sub-G1 DNA content in the presence of mutant p53.
References	[1]. Bykov VJ, et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs [published correction appears in J Biol Chem. 2017 Dec 1;292(48):19607]. J Biol Chem. 2005;280(34):30384-30391.

Density	1.307g/cm3
Boiling Point	298.2ºC at 760 mmHg
Molecular Formula	C₈H₉NO₄
Molecular Weight	183.16
Flash Point	134.1ºC
Exact Mass	183.05300
PSA	63.68000
Index of Refraction	1.514
Storage condition	2-8°C

5063-96-7 structure

5063-96-7

123-62-6 structure

123-62-6

~%

72835-26-8 structure

72835-26-8

Literature: U.S.Rubber Co. Patent: US2790787 , 1953 ;

Precursor 2
5063-96-7 123-62-6
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