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84477-87-2

84477-87-2 structure
84477-87-2 structure
  • Name: H-7
  • Chemical Name: 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
  • CAS Number: 84477-87-2
  • Molecular Formula: C14H17N3O2S
  • Molecular Weight: 291.36900
  • Create Date: 2018-10-06 10:23:20
  • Modify Date: 2024-01-02 20:56:51
  • Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].
Name 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
Synonyms H-7 dihydrochloride,(±)-1-(5-Isoquinolinesulphonyl)-2-methylpiperazinedihydrochloride
H-7
H-72HCl
Description Protein kinase inhibitor H-7 is a potent inhibitor of protein kinase C (PKC) and cyclic nucleotide dependent protein kinase, with a Ki of 6 μM for PKC[1].
Related Catalog
Target

PKC:6 μM (Ki)
References

[1]. Hidaka H, et, al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41.

Density 1.277 g/cm3
Boiling Point 495.3ºC at 760 mmHg
Melting Point 114 °C
Molecular Formula C14H17N3O2S
Molecular Weight 291.36900
Flash Point 253.3ºC
Exact Mass 291.10400
PSA 70.68000
LogP 2.56470
Index of Refraction 1.652
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL9305000
CHEMICAL NAME :
Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-
CAS REGISTRY NUMBER :
84477-87-2
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H17-N3-O2-S
MOLECULAR WEIGHT :
291.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EJCTEA European Journal of Cancer Part A. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.28A(4/5)- 1992- Volume(issue)/page/year: 30A,525,1994
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TL9305000
HS Code 2935009090
84477-86-1 structure

84477-86-1

~%

84477-87-2 structure

84477-87-2
Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
109-07-9 structure

109-07-9

~%

84477-87-2 structure

84477-87-2
Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
84477-85-0 structure

84477-85-0

~%

84477-87-2 structure

84477-87-2
Literature: Morikawa; Sone; Asano Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 3 p. 770 - 773
Precursor  3

DownStream  0

HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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