Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S-(7-OXO-7-((4-PHENYLTHIAZOL-2-YL)AMINO)HEPTYL) 2-METHYLPROPANETHIOATE
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Purity: 98.0%
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848354-66-5

848354-66-5 structure

Name: NCH 51
Chemical Name: S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate
CAS Number: 848354-66-5
Molecular Formula: C₂₀H₂₆N₂O₂S₂
Molecular Weight: 390.563
Catalog: Research Areas Cancer
Create Date: 2017-12-31 05:02:58
Modify Date: 2024-01-08 11:23:27
PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.IC50 value: 1-10 μM (EC50)Target: HDACin vitro: In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.

Name	S-[7-oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl] 2-methylpropanethioate
Synonyms	Propanethioic acid, 2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester NCH 51 Cpd 51 PTACH S-{7-Oxo-7-[(4-phenyl-1,3-thiazol-2-yl)amino]heptyl} 2-methylpropanethioate thioisobutyric acid S-(6-(4-phenyl-2-thiazolylcarbamoyl)hexyl) ester

Description	PTACH (NCH-51) is a SAHA-based novel inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.IC50 value: 1-10 μM (EC50)Target: HDACin vitro: In cancer cell growth inhibition assay, PTACH shows strong activity. PTACH inhibits various cancer cells with EC50 of 2.3, 9.1, 3.0, 2.6, 1.1, 4.5, 2.4, 5.0, and 4.5 μM for MDA-MB-231 breast cancer, SNB-78 central nervous system, HCT116 colon cancer, NCI-H226 lung cancer, LOX-IMVI melanoma, SK-OV-3 ovarian cancer, RXF-631L renal cancer, St-4 stomach cancer, and DU-145 prostate cancer.
Related Catalog	Research Areas >> Cancer
Target	HDAC
References	[1]. Suzuki T, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-1032.

Symbol	GHS05
Signal Word	Danger
Hazard Statements	H318-H413
Precautionary Statements	P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	41
Safety Phrases	26-39
RIDADR	NONH for all modes of transport
HS Code	2934100090

HS Code	2934100090
Summary	2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%