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Product Name: 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
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87081-35-4

87081-35-4 structure

Name: Leptomycin B
Chemical Name: leptomycin B
CAS Number: 87081-35-4
Molecular Formula: C₃₃H₄₈O₆
Molecular Weight: 540.73
Catalog: API Antibiotics Other antibiotics
Create Date: 2018-06-10 12:04:12
Modify Date: 2026-07-17 23:37:56
Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle[1].

Name	leptomycin B
Synonyms	Ltomycin B solutio Leptomycin B,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid NSC 364372 CL 1957A Ltomycin B Antibiotic CI 940 Antibiotic CL 1957A Ltomycin B (5 μg/mL in Ethanol) 2,10,12,16,18-nonadecapentanoicacid,19-(3,6-dihydro-3-methyl-6-oxo-2h-pyran-2 Elactocin, ATS 1287B, CI 940, CL 1957A, PD 114720, MantuaMycin LTOMYCIN B (2E,5S,6R,7S,9R,10E,12E,15R,16E,18E)-17-Ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxo-2,10,12,16,18-nonadecapentaenoic acid 2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo LTOMYCIN B FROM STRTOMYCES SP antibioticcl1957a LEPTOMYCIN B FROM STREPTOMYCES SP 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E) (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid Ltomycin B (ethanol solution), Antibiotic, antifungal. Inhibitor of CRM-1 mediated nucleexport Lrimycin B Ltomycin B (0.2mg/ml) CI-940, Elactocin, PD 114720, ATS 1287B, Mantuamycin, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-Nonadecapentaenoic acid (2E,10Z,12E,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxo-nonadeca-2,10,12,16,18-pentaenoic acid InSolution Ltomycin B Ltomycin B, 10 mM in DMSO Lomycin B 2,10,12,16,18-nonadecapentaenoic acid Ltomycin B (CI LTOMYCIN B FROM STRTOMYCES SP //BP antibioticci940 2,10,12,16,18-Nonadecapentaenoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo Ltomycin B solution from Strtomyces sp XPO1,Chromosomal Maintenance 1,Fungal,inhibit,CI-940,EMT,Antibiotic,Ltomycin B,p53,nucleexport,mutation,EGFR,NSCLC,resistance,Inhibitor,CRM1,CI940,cancer,Exportin 1,KRAS InSolution Ltomycin B, Strtomyces sp. - - Calbiochem 7,9,11,15-hexamethyl-8-oxo-yl)-17-ethyl-6-hydroxy-5 7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5 (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-Ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-((2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid LtoMycin B soluton Ltomycin B, Strtomyces sp (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-Ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

Description	Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Membrane Transporter/Ion Channel >> CRM1
Target	CRM1/exportin 1[1]
References	[1]. Kudo N, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9112-7.

Density	1.1±0.1 g/cm3
Boiling Point	725.8±60.0 °C at 760 mmHg
Melting Point	41-44ºC
Molecular Formula	C₃₃H₄₈O₆
Molecular Weight	540.73
Flash Point	224.8±26.4 °C
Exact Mass	540.345093
PSA	100.90000
LogP	6.66
Vapour Pressure	0.0±5.3 mmHg at 25°C
Index of Refraction	1.542

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5390000

CHEMICAL NAME :: 2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethy l- 6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-

CAS REGISTRY NUMBER :: 87081-35-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C33-H48-O6

MOLECULAR WEIGHT :: 540.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,253,1985

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301-H311-H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	T: Toxic;F: Flammable;
Risk Phrases	R23/25
Safety Phrases	7-16-24-33-45
RIDADR	UN 1230 3
WGK Germany	3
HS Code	2916190090

Precursor 3
217640-04-5 217640-11-4 217640-14-7
DownStream 0

HS Code	2916190090
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

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