Leptomycin B

Modify Date: 2024-01-04 05:35:23

Leptomycin B structure	Common Name	Leptomycin B
	CAS Number	87081-35-4	Molecular Weight	540.73
	Density	1.1±0.1 g/cm3	Boiling Point	725.8±60.0 °C at 760 mmHg
	Molecular Formula	C₃₃H₄₈O₆	Melting Point	41-44ºC
	MSDS	N/A	Flash Point	224.8±26.4 °C
	Symbol	GHS02, GHS06, GHS08	Signal Word	Danger

Use of Leptomycin B

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle[1].

Name	leptomycin B
Synonym	More Synonyms

Description	Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Membrane Transporter/Ion Channel >> CRM1
Target	CRM1/exportin 1[1]
References	[1]. Kudo N, et al. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9112-7.

Density	1.1±0.1 g/cm3
Boiling Point	725.8±60.0 °C at 760 mmHg
Melting Point	41-44ºC
Molecular Formula	C₃₃H₄₈O₆
Molecular Weight	540.73
Flash Point	224.8±26.4 °C
Exact Mass	540.345093
PSA	100.90000
LogP	6.66
Vapour Pressure	0.0±5.3 mmHg at 25°C
Index of Refraction	1.542

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RA5390000

CHEMICAL NAME :: 2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethy l- 6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-

CAS REGISTRY NUMBER :: 87081-35-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C33-H48-O6

MOLECULAR WEIGHT :: 540.81

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 1 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,253,1985

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301-H311-H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
Hazard Codes	T: Toxic;F: Flammable;
Risk Phrases	R23/25
Safety Phrases	7-16-24-33-45
RIDADR	UN 1230 3
WGK Germany	3
HS Code	2916190090

Precursor 3
CAS#:217640-04-5 (2R,3S)-1-(benz... CAS#:217640-11-4 (S)-4-isopropyl... CAS#:217640-14-7 (2S,3R,4S,E)-3-...
DownStream 0

HS Code	2916190090
Summary	2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses.

J. Virol. 89(9) , 4918-31, (2015)

The ORF45 protein of Kaposi's sarcoma-associated herpesvirus (KSHV) is a gammaherpesvirus-specific immediate-early tegument protein. Our previous studies have revealed its crucial roles in both early ...

African swine fever virus ORF P1192R codes for a functional type II DNA topoisomerase.

Virology 474 , 82-93, (2014)

Topoisomerases modulate the topological state of DNA during processes, such as replication and transcription, that cause overwinding and/or underwinding of the DNA. African swine fever virus (ASFV) is...

Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.

Nat. Commun. 5 , 5437, (2014)

Cells cope with replication-blocking lesions via translesion DNA synthesis (TLS). TLS is carried out by low-fidelity DNA polymerases that replicate across lesions, thereby preventing genome instabilit...

Leptomycin B,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoicacid

2,10,12,16,18-nonadecapentaenoic acid

2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-, (2E,5S,6R,7S,9R,10E,12E,15R,16E,18E)-

2,10,12,16,18-Nonadecapentaenoic acid, 19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-, (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-

7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5

(2E,5S,6R,7S,9R,10E,12E,15R,16E,18E)-17-Ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

antibioticci940

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-Ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-3,6-dihydro-2H-pyran-2-yl]-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

antibioticcl1957a

LEPTOMYCIN B FROM STREPTOMYCES SP

Leptomycin B

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Leptomycin B
Price: ￥Inquiry/1mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Leptomycin B
Price: $Inquiry/100mg
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,10,12,16,18-Nonadecapentaenoicacid,19-[(2S,3S)-3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-,(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥3200/0.046 mM * 200 uL in Ethanol

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Leptomycin B

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