Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt
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93839-89-5

93839-89-5 structure

Name: Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt
Chemical Name: ATPγS tetralithium salt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsalt
CAS Number: 93839-89-5
Molecular Formula: C₁₀H₁₂Li₄N₅O₁₂P₃S
Molecular Weight: 546.979
Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
Create Date: 2019-01-01 12:41:00
Modify Date: 2026-08-14 12:04:13
ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1].

Name	ATPγS tetralithium salt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsalt
Synonyms	adenosine-5’-o-(3-thiotriphosphate)(atp-g-s),sodiumsalt ATP-GAMMA-S, 4LI Adenosine 5μ-(3-thiotriphosphate) tetralithium salt, Ado-5μ-PPP[S], ATP-γ-S Adenosine 5′-[γ-thio]triphosphate tetralithium salt ATP-gamma-S, Kinase substrate Tetralithium 5'-O-[({[(dioxidophosphorothioyl)oxy]phosphinato}oxy)phosphinato]adenosine ADENOSINE-5'-O-(3-THIOPHOSPHATE) LI4 Adenosine 5'-(γ-thio)-triphosphate (lithium salt) (ATPγS) ADENOSINE-5'-O-(3-THIOTRIPHOSPHATE) LITHIUM SALT ADENOSINE 5'-O-(3-THIOTRIPHOSPHATE)TETRA LITHIUM ADENOSINE-5'-[GAMMA-THIO]TRIPHOSPHATE TETRALITHIUM SALT ATP-GAMMA-S LI4 Adenosine 5'-γ-thiotriphosphoric acid tetrakislithium salt ADENOSINE-5'-O-(3-THIOTRIPHOSPHORIC ACID), SODIUM Adenosine 5'-(3-thiotriphosphate)trilithium salt Adenosine 5'-(γ-thiotriphosphoric acid)tetralithium salt Adenosine 5’-[Gamma-thio]triphosphate Tetralithium Salt Adenosine 5'-(γ-thiotriphosphoric acid α,β,γ,γ-tetrakislithium) salt ATP-GAMMA-S SODIUM SALT Adenosine 5'-(trihydrogen diphosphate),P '-anhydride with phosphorothioic acid,tetralithium salt ADO-5'-PPP[S] 4LI Adenosine 5-O-(3-Thiotriphosphate), Solution, Tetralithium Salt ATP-GAMMA-S LITHIUM SALT Adenosine 5’[γ-thio]triphosphate Tetralithium Salt ATP-γ-S S tetralithium salt ADENOSINE-5'-(GAMMA-THIO)TRIPHOSPHATE TE ATPγStetralithiumsalt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsal Adenosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetralithium salt Adenosine 5'-(γ-thio)-triphosphate (lithium salt) Adenosine-5''-O-(3-thiotriphosphoric acid) tetralithium salt ADENOSINE-5'-)Y-THIO)TRIPHOSPHATE TETRALITHIUM SALT ATP-GAMMA-S TETRALITHIUM SALT ADENOSINE-5'-O-(3-THIOTRIPHOSPHORIC ACID), TETRALITHIUM ATPγS tetralithium salt ADENOSINE 5'-O-(3-THIOTRIPHOSPHATE), TETRALITHIUM SALT ATPgammaS tetralithi Adenosine- 5'- O- (3- thiotriphosphate) ( ATP-γ-S ) Sigma Adenosine 5'-[gamma-thio]triphosphate tetralithium salt Adenosine 5'-α-thiotriphosphoric acid Adenosine 5'-[γ-thio]triphosphate tetralithium salt;Ado-5'-PPP[S];ATP-γ-S;Adenosine 5'-(3-thiotriphosphate)trilithium salt Adenosine 5′-[γ-thio]triphosphate ADENOSINE 5'-(3-THIOTRIPHOSPHATE) TETRALITHIUM SALT Ado-5'-PPP[S] Adenosine 5'-[γ-thio]triphosphate tetralithium salt Adenosine 5′-(trihydrogen diphosphate), P′-anhydride with phosphorothioic acid, tetralithium salt ADENOSINE-5'-O-(3-THIOTRIPHOSPHATE) SODIUM SALT ATP-ALPHA-S, NA Adenosine, 5'-O-[hydroxy[[hydroxy[(hydroxymercaptophosphinyl)oxy]phosphinyl]oxy]phosphinyl]-, lithium salt (1:4)

Description	ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Eukaryotic Initiation Factor (eIF) Research Areas >> Inflammation/Immunology
In Vitro	ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1]. ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3].
In Vivo	ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3]. ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3].
References	[1]. Matthew L Peck, et al. Adenosine 5'-O-(3-thio)triphosphate (ATPgammaS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A. RNA. 2003 Oct;9(10):1180-7. [2]. Z Y Wang, et al. Mg2+ and ATP or adenosine 5'-[gamma-thio]-triphosphate (ATP gamma S) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase. Biochim Biophys Acta. 1993 Sep 3;1202(1):47-55. [3]. Irina A Kolosova, et al. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2008 Feb;294(2):L319-24.

Boiling Point	940.5ºC at 760 mmHg
Molecular Formula	C₁₀H₁₂Li₄N₅O₁₂P₃S
Molecular Weight	546.979
Flash Point	522.6ºC
Exact Mass	547.005615
PSA	334.90000
LogP	1.47200

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

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