93839-89-5
93839-89-5 structure
- Name: Adenosine 5'-[γ-thio]triphosphate Tetralithium Salt
- Chemical Name: ATPγS tetralithium salt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsalt
- CAS Number: 93839-89-5
- Molecular Formula: C10H12Li4N5O12P3S
- Molecular Weight: 546.979
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
- Create Date: 2019-01-01 12:41:00
- Modify Date: 2024-01-03 08:11:16
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ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1].
| Name | ATPγS tetralithium salt,Adenosine-5'-(γ-thio)-triphosphatetetralithiumsalt |
|---|---|
| Synonyms |
Tetralithium 5'-O-[({[(dioxidophosphorothioyl)oxy]phosphinato}oxy)phosphinato]adenosine
Adenosine, 5'-O-[hydroxy[[hydroxy[(hydroxymercaptophosphinyl)oxy]phosphinyl]oxy]phosphinyl]-, lithium salt (1:4) |
| Description | ATPγS (tetralithium salt) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor eIF4A[1]. |
|---|---|
| Related Catalog | |
| In Vitro | ATPγS (tetralithium salt) enhances intrinsic fluorescence and induces aggregation which increases the activity of spinach Rubisco activase[1]. ATPγS (50-100 μM final blood concentration) attenuates inflammatory response with decreased accumulation of cells (48%, P < 0.01) and proteins (57%, P < 0.01) in bronchoalveolar lavage and reduces neutrophil infiltration and extravasation of Evans blue albumin dye into lung tissue[3]. |
| In Vivo | ATPγS (tetralithium salt, 50 μM final, intravenous) demonstrates preserved lung parenchymal architecture[3]. ATPγS results in a dose-dependent effect on EBA extravasation in LPS-treated mice[3]. |
| References |
| Boiling Point | 940.5ºC at 760 mmHg |
|---|---|
| Molecular Formula | C10H12Li4N5O12P3S |
| Molecular Weight | 546.979 |
| Flash Point | 522.6ºC |
| Exact Mass | 547.005615 |
| PSA | 334.90000 |
| LogP | 1.47200 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |