636-47-5
636-47-5 structure
- Name: 1H-Pyrrole-2-carboxamide,N-[5-[[(3-amino-3-iminopropyl)amino]carbonyl]-1-methyl-1H-pyrrol-3-yl]-4-[[[4-(formylamino)-1-methyl-1H-pyrrol-2-yl]carbonyl]amino]-1-methyl-
- Chemical Name: distamycin a
- CAS Number: 636-47-5
- Molecular Formula: C22H27N9O4
- Molecular Weight: 481.50800
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-09-28 19:11:24
- Modify Date: 2024-01-04 18:37:21
-
Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis[1][2][3].
| Name | distamycin a |
|---|---|
| Synonyms |
stallimycin
Distamycin-3 Distamycin |
| Description | Distamycin A (NSC-82150), an oligopeptide antibiotic, is a minor groove binder which binds to B-form DNA, preferentially at A/T rich sites.Distamycin A can change Enediyne-induced DNA cleavage sites and enhances apoptosis[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Distamycin A 与 DNA 结合，通过伸直螺旋轴并将其延长近 12-15% 来加宽小沟[2]。 Distamycin A 增强 5'-CCT-3'/3'-GGA-5' 和 5'-CCA-3'/3'-GGT-5' 序列的双链 DNA 切割[3]< /sup>. Distamycin A 在 HL-60 细胞中增强 C1027 诱导的 DNA 阶梯形成和细胞毒性[3]。 |
| References |
[1]. ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5. |
| Density | 1.45g/cm3 |
|---|---|
| Molecular Formula | C22H27N9O4 |
| Molecular Weight | 481.50800 |
| Exact Mass | 481.21900 |
| PSA | 181.06000 |
| LogP | 2.87670 |
| Index of Refraction | 1.69 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
|
| Precursor 6 | |
|---|---|
| DownStream 0 | |
![3-[1-methyl-4-[1-methyl-4-(1-methyl-4-aminopyrrole-2-carboxamido)pyrrole-2-carboxamido]pyrrole-2-carboxamido]propionitrile structure](https://www.chemsrc.com/caspic/245/121541-72-8.png)
![methyl 1-methyl-4-[[1-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]pyrrole-2-carbonyl]amino]pyrrole-2-carboxylate structure](https://www.chemsrc.com/caspic/083/126092-97-5.png)
![methyl 4-[[[4-[[[4-[[(tert-butyloxy)carbonyl]amino]-1-methyl-pyrrol-2-yl]carbonyl]amino]-1-methyl-pyrrol-2-yl]carbonyl]amino]-1-methyl-pyrrole-2-carboxylic acid structure](https://www.chemsrc.com/caspic/348/126093-01-4.png)
