636-47-5

636-47-5结构式
636-47-5结构式

化源商城直购

中文名 司他霉素
英文名 distamycin a
英文别名 stallimycin
Distamycin-3
Distamycin
描述 Distamycin A(NSC-82150)是一种寡肽抗生素,是一种与B型DNA结合的小凹槽粘合剂,优先在富含A/T的位点。Distamycine A可以改变Enediyne诱导的DNA切割位点,并增强细胞凋亡[1][2][3]。
相关类别
体外研究 曲霉素A与 脱氧核糖核酸结合,通过伸直螺旋轴并将其延长近 12-15% 来加宽小沟[2]。 曲霉素A增强 5’-ccct-3’/3’-GGA-5’和 5’-CCA-3’/3’-GGT-5’序列的双链 脱氧核糖核酸切割[3] 。曲霉素A在 HL-60型细胞中增强 第1027页诱导的 脱氧核糖核酸阶梯形成和细胞毒性[3]。
参考文献

[1]. ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5.  

[2]. Hiraku Y, et, al. Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis. Nucleic Acids Res Suppl. 2002;(2):95-6.  

[3]. Majumder P, et, al. Effect of DNA groove binder distamycin A upon chromatin structure. PLoS One. 2011;6(10):e26486.  

密度 1.45g/cm3
分子式 C22H27N9O4
分子量 481.50800
精确质量 481.21900
PSA 181.06000
LogP 2.87670
折射率 1.69

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WZ7108000
CAS REGISTRY NUMBER :
636-47-5
LAST UPDATED :
199612
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C22-H27-N9-O4
MOLECULAR WEIGHT :
481.58
WISWESSER LINE NOTATION :
T5NJ A1 BVM2YZUM DMV- BT5NJ A1 DMV- BT5NJ A1 DMVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
72 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA damage
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
500 umol/L
REFERENCE :
MLBRBU Molecular Biology Reports. (Dr. W. Junk Pub., POB 163, 3300 AD Dordrect, Netherlands) V.1- 1973- Volume(issue)/page/year: 2,135,1975