52934-83-5
52934-83-5 structure
- Name: Nanafrocin
- Chemical Name: nanaomycin A
- CAS Number: 52934-83-5
- Molecular Formula: C16H14O6
- Molecular Weight: 302.279
- Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
- Create Date: 2018-08-25 15:12:19
- Modify Date: 2024-01-02 16:37:49
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Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].
| Name | nanaomycin A |
|---|---|
| Synonyms |
(1S-E)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic Acid
4-deoxykalafunginic acid 1H-Naphtho[2,3-c]pyran-3-acetic acid, 3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-, (1S,3R)- dihydrokalafungin 2-[(1S,3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4-dihydro-1H-benzo[g]isochromen-3-yl]acetic acid Rosanomycin A Nanafrocine Nanafrocinum nanaomycin A nanafrocinum [INN_la] (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic Acid OS 3966-A [(1S,3R)-9-Hydroxy-1-methyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-benzo[g]isochromen-3-yl]acetic acid Nanafrocin |
| Description | Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2]. |
|---|---|
| Related Catalog | |
| Target |
DNMT3B:500 nM (IC50) |
| In Vitro | Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines[1]. Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells[1]. Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction[1]. Nanaomycin A not affects the enzymatic activity of DNMT1[1]. Cell Cytotoxicity Assay[1] Cell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines Concentration: 10, 100, 1000, 10000 nM Incubation Time: 72 hours Result: Had a distinct cytotoxic effect in all three cell lines. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 0.5, 5 μM Incubation Time: 72 hours Result: Revealed induction of RASSF1A protein expression. RT-PCR[1] Cell Line: A549 cells Concentration: 5 μM Incubation Time: 72 hours Result: Had an 18-fold relative induction. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 601.5±55.0 °C at 760 mmHg |
| Molecular Formula | C16H14O6 |
| Molecular Weight | 302.279 |
| Flash Point | 229.0±25.0 °C |
| Exact Mass | 302.079041 |
| PSA | 100.90000 |
| LogP | 2.60 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.649 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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