Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-
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11033-22-0

11033-22-0 structure

Name: Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-
Chemical Name: coformycin
CAS Number: 11033-22-0
Molecular Formula: C₁₁H₁₆N₄O₅
Molecular Weight: 284.26900
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2017-12-05 05:02:31
Modify Date: 2024-01-11 18:12:03
Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

Name	coformycin
Synonyms	Coformycin

Description	Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc[2]. Animal Model: Swiss-Webster mice[2]. Dosage: 0.2 mg/kg. Administration: IP daily. Result: Inhibited adenosine deaminase activity for various tissues.
References	[1]. Coformycin. [2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.

CHEMICAL NAME :: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,330,1981