Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

Modify Date: 2024-01-11 18:12:03

Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)- structure	Common Name	Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-
	CAS Number	11033-22-0	Molecular Weight	284.26900
	Density	1.96g/cm3	Boiling Point	692.7ºC at 760mmHg
	Molecular Formula	C₁₁H₁₆N₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	372.7ºC

Use of Imidazo[4,5-d][1,3]diazepin-8-ol,3,4,7,8-tetrahydro-3-b-D-ribofuranosyl-, (8R)-

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

Name	coformycin
Synonym	More Synonyms

Description	Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Adenosine Deaminase Signaling Pathways >> Anti-infection >> Bacterial
In Vivo	Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc[2]. Animal Model: Swiss-Webster mice[2]. Dosage: 0.2 mg/kg. Administration: IP daily. Result: Inhibited adenosine deaminase activity for various tissues.
References	[1]. Coformycin. [2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.

Density	1.96g/cm3
Boiling Point	692.7ºC at 760mmHg
Molecular Formula	C₁₁H₁₆N₄O₅
Molecular Weight	284.26900
Flash Point	372.7ºC
Exact Mass	284.11200
PSA	132.36000
Vapour Pressure	3.84E-20mmHg at 25°C
Index of Refraction	1.828

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI2931500

CHEMICAL NAME :: Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-

CAS REGISTRY NUMBER :: 11033-22-0

LAST UPDATED :: 198311

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C11-H16-N4-O5

MOLECULAR WEIGHT :: 284.31

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,330,1981

Coformycin