Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Boc-cis-4-Hydroxy-D-proline
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Purity: 98.0%
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135042-12-5

135042-12-5 structure

Name: N-Boc-cis-4-Hydroxy-D-proline
Chemical Name: Boc-Cis-4-Hydroxy-D-Proline
CAS Number: 135042-12-5
Molecular Formula: C₁₀H₁₇NO₅
Molecular Weight: 231.246
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2018-12-28 14:27:53
Modify Date: 2026-06-30 18:10:41
N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth

Name	Boc-Cis-4-Hydroxy-D-Proline
Synonyms	N-BOC-CIS-6-HYDROXY-D-PROLINE (2R,4R)-N-Boc-4-hydroxypyrrolidine-2-cboxylic acid //BP N-Boc-cis-D-Hyp-OH 1-(1,1-Dimethylethyl) (2R,4R)-4-hydroxy-1,2-pyrrolidinedicboxylate (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline N-T-BOC-CIS-4-HYDROXY-D-PROLINE (2R,4R)-1-BOC-4-Hydroxy-pyrrolidine-2-cboxylic acid (2R,4R)-N-ALPHA-T-BUTOXYCBONYL-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID Boc-cis-D-Hyp-OH (2R,4R)-N-Boc-cis-4-hydroxy-D-proline (4R)-1-(tert-Butoxycbonyl)-4-hydroxy-D-proline (2R,4R)-N-BOC-4-HYDROXY-D-PROLINE cis-N-Boc-4-hydroxy-D-proline N-α-(t-Butoxycbonyl)-cis-4-hydroxy-D-proline (2R,4R)-1-tert-Butoxycbonyl-4-hydroxypyrrolidine-2-cboxylic acid (2R,4R)-4-Hydroxypyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester N-Boc-cis-4-hydroxy- D -proline (2R,4R)N-Boc-trans-4-hydroxy-D-proline (2R,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (2r,4r)-n-boc-4-hydroxypyrrolidine-2-cboxylic acid (4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R,4R) N-Boc-D-cis-Hyp-OH (Tert-Butoxy)carbonyl cis-D-Hyp-OH ATTERCOP-CHM AT700573 (2R,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecarboxylic acid BOC-CIS-4-HYDROXY-D-PROLINE BOC-D-CISHYP-OH cis-Boc-D-Hyp-OH N-ALPHA-BUTOXYCBONYL-CIS-4-HYDROXY-D-PROLINE N-BOC-CIS-4-HYDROXY-D-PROLINE Boc-cis-4-hydroxy-D-proL 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R-cis) cis-N-(tert-Butoxycbonyl)-4-hydroxy-D-proline (2R,4R)-N-Boc-4-hydroxy-2-pyrrolidinecboxylic acid MFCD02094407 BOC-(2R,4R)-(+)-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID

Description	N-Boc-cis-4-Hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-Hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synth
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Density	1.3±0.1 g/cm3
Boiling Point	390.9±42.0 °C at 760 mmHg
Melting Point	145ºC
Molecular Formula	C₁₀H₁₇NO₅
Molecular Weight	231.246
Flash Point	190.2±27.9 °C
Exact Mass	231.110672
PSA	87.07000
LogP	-0.71
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.531
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26
RIDADR	NONH for all modes of transport
HS Code	2933990090

Precursor 9
24424-99-5 2584-71-6 1070-19-5 77449-94-6
77450-00-1 295365-33-2 502442-57-1 502442-63-9
502442-61-7
DownStream 8
364077-84-9 141850-54-6 200184-87-8 200184-86-7
135042-30-7 2584-71-6 256487-77-1 77450-03-4

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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