- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
- Price: Check
- Purity: 99.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
- Price: ￥918.0/250mg ￥2878.0/1g
- Purity: 99.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
- Price: ￥Inquiry/10g
- Purity: 98.0%
- Stocking Period: 14 Day
- Contact: Lihua Yang
- Email: sales@pu-kang.com
- DC Chemicals Limited
- China
- Product Name: N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: N-tert-Boc-trans-4-Hydroxy-D-proline
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
147266-92-0
147266-92-0 structure
- Name: N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
- Chemical Name: (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
- CAS Number: 147266-92-0
- Molecular Formula: C10H17NO5
- Molecular Weight: 231.246
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-12-29 15:20:46
- Modify Date: 2025-08-26 17:51:53
-
N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
| Name | (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid |
|---|---|
| Synonyms |
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline
Boc-trans-4-Hydroxy-D-proline 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2R,4S)- N-Boc-trans-4-hydroxy-D-proline MFCD01861341 |
| Description | N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
| Melting Point | 123ºC |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.246 |
| Flash Point | 190.2±27.9 °C |
| Exact Mass | 231.110672 |
| PSA | 87.07000 |
| LogP | -0.71 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
|
~88%
147266-92-0 |
| Literature: LG LIFE SCIENCES LTD. Patent: WO2010/56022 A2, 2010 ; Location in patent: Page/Page column 21 ; WO 2010/056022 A2 |
|
~99%
147266-92-0 |
| Literature: Fransson, Rebecca; McCracken, Alison N.; Chen, Bin; McMonigle, Ryan J.; Edinger, Aimee L.; Hanessian, Stephen ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 969 - 973 |
|
~99%
147266-92-0 |
| Literature: Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453 |
|
~%
147266-92-0 |
| Literature: Journal of Organic Chemistry, , vol. 70, # 16 p. 6447 - 6453 |
|
~%
147266-92-0 |
| Literature: RSC Advances, , vol. 4, # 5 p. 2482 - 2490 |
|
~%
147266-92-0 |
| Literature: RSC Advances, , vol. 4, # 5 p. 2482 - 2490 |
|
~%
147266-92-0 |
| Literature: RSC Advances, , vol. 4, # 5 p. 2482 - 2490 |
| Precursor 6 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |