147266-92-0
147266-92-0 structure
- Name: N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline
- Chemical Name: (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid
- CAS Number: 147266-92-0
- Molecular Formula: C10H17NO5
- Molecular Weight: 231.246
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-12-29 15:20:46
- Modify Date: 2026-07-01 06:14:42
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N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
| Name | (2R,4S)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid |
|---|---|
| Synonyms |
N-Boc-trans-4-Hydroxy-D-proline
(4S)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-proline Boc-trans-4-Hydroxy-D-proline trans-1-[(tert-butoxy)carbonyl]-4-hydroxypyrrolidine-2-cboxylic acid 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R,4S) (2R,4S)-1-(tert-butoxycbonyl)-4-hydroxypyrrolidine-2-cboxylic acid/N-tert-butoxycbonyl-D-trans-4-hydroxyproline 1-(1,1-Dimethylethyl) (2R,4S)-4-hydroxy-1,2-pyrrolidinedicboxylate (2R,4S)-4-Hydroxy-pyrrolidine-1,2-dicboxylic acid 1-tert-butyl ester Prusogliptin Impurity 16 (2R,4S)-4-Hydroxy-1,2-pyrrolidinedicboxylic acid 1-(tert-butyl) ester (2R,4S)-N-ALPHA-T-BUTOXYCBONYL-4-HYDROXYPYRROLIDINE-2-CB N-Boc-trans-4-hydroxy- D -proline BOC-D-PRO(4-HYDROXY)-OH Boc-D-trans-Hyp-OH BOC-D-HYP-OH Teneligliptin Impurity 27 (2R,4S)-N-ALPHA-T-BUTOXYCBONYL-4-HYDROXYPYRROLIDINE-2-CBO (2R,4s)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycbonyl]pyrrolidine-2-cboxylic acid 1-(tert-Butyl) (2R,4S)-4-hydroxy-1,2-pyrrolidinedicboxylate (Tert-Butoxy)carbonyl D-trans-Hyp-OH MFCD01861341 N-Boc-trans-D-Hyp-OH N-tert-Butoxycbonyl-trans-4-hydroxy-D-proline Tenteligliptin impurity 2 (2R,4S)-1-(tert-butoxycbonyl)-4-hydroxypyrrolidine-2- cboxylic acid (2R,4S)-N-ALPHA-T-BUTOXYCBONYL-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID (2R,4S)-N-Boc-cis-4-hydroxy-D-proline N-T-BOC-TRANS-4-HYDROXY-D-PROLINE 1,2-Pyrrolidinedicboxylic acid, 4-hydroxy-, 1-(1,1-diMethylethyl) ester, (2R-trans) (2R,4S)-N-ALPHA-T-BUTOXYCBONYL-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID //BP (2R,4S)-N-Boc-4-hydroxy-D-proline N-BOC-CIS-7-HYDROXY-D-PROLINE (2R,4S)-1-(tert-Butoxycbonyl)-4-hydroxypyrrolidine-2-c Boc-(2R,4S)-4-hydroxypyrrolidine-2-cboxylic acid (2R,4S)-N-Boc-trans-4-hydroxy-D-proline N-tert-butoxycbonyl-D-trans-4- hydroxyproline Boc-trans-4-hydroxy-D-proline (NMR) (2R,4S)-1-(tert-butoxycbonyl)-4-hydroxypyrrolidine-2-cboxylic acid N-Boc-trans-4-hydroxy-D-proline N-ALPHA-T-BUTOXYCBONYL-D-HYDROXYPROLINE (2R,4S)-1-(tert-Butoxycbonyl)-4-hydroxypyrrolidine-2-cboxylicaci trans-Boc-D-Hpy-OH 1-tert-Butoxycbonyl-(2R,4S)-4-hydroxypyrrolidine-2-cboxylic acid Boc-trans-D-Hyp-OH BOC-TRANS-4-HYDROXY-D-PROLINE |
| Description | N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-tert-Butoxycarbonyl-trans-4-hydroxy-D-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
| Melting Point | 123ºC |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.246 |
| Flash Point | 190.2±27.9 °C |
| Exact Mass | 231.110672 |
| PSA | 87.07000 |
| LogP | -0.71 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
|
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147266-92-0 |
| Literature: LG LIFE SCIENCES LTD. Patent: WO2010/56022 A2, 2010 ; Location in patent: Page/Page column 21 ; WO 2010/056022 A2 |
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| Literature: Fransson, Rebecca; McCracken, Alison N.; Chen, Bin; McMonigle, Ryan J.; Edinger, Aimee L.; Hanessian, Stephen ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 10 p. 969 - 973 |
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147266-92-0 |
| Literature: Koskinen, Ari M. P.; Helaja, Juho; Kumpulainen, Esa T. T.; Koivisto, Jari; Mansikkamaeki, Heidi; Rissanen, Kari Journal of Organic Chemistry, 2005 , vol. 70, # 16 p. 6447 - 6453 |
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| Literature: Journal of Organic Chemistry, , vol. 70, # 16 p. 6447 - 6453 |
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| Literature: RSC Advances, , vol. 4, # 5 p. 2482 - 2490 |
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| Literature: RSC Advances, , vol. 4, # 5 p. 2482 - 2490 |
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| Literature: RSC Advances, , vol. 4, # 5 p. 2482 - 2490 |
| Precursor 6 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |