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51-35-4

51-35-4 structure

51-35-4 structure

Name: L-Hydroxyproline
Chemical Name: 4-hydroxy-L-proline
CAS Number: 51-35-4
Molecular Formula: C₅H₉NO₃
Molecular Weight: 131.130
Catalog: Biochemical Amino acids and their derivatives Proline derivatives
Create Date: 2018-09-10 10:45:17
Modify Date: 2026-06-30 15:02:45
L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.

Name	4-hydroxy-L-proline
Synonyms	trans-4-Hydroxy-L-proline, (4R)-4-Hydroxy-L-proline Pyrrolidin-4-ol-2-cboxylic acid MFCD00064320 H-TRANS-HYP-OH (2S,4R)-4-Hydroxypyrrolidine-2-cboxylic allo-4-Hydroxyproline trans-L-4-hydroxyproline 4R-4-hydroxyproline L-4-HYDROXY-2-PYRROLIDINECBOXYLIC ACID L-TRANS-4-HYDROXYPROLINE TRANS-4-HYDROXY-L-PROLINE HydroxyproL 4-HYDROXY-L-PROLINE H-HYP-OH L-HYP HYDROXY-L-PROLINE, trans-4-(RG) oxyproline dec-2t-ene-4,6-diyn-1-ol Proline, 4-hydroxy- (VAN) Trans-4-hydroxy-proline -L (2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid L-HYDROXYPROLINE-4 HYDROXYPROLINE L-HYDROXYPROLINE L-HYDROXYPROLINE extrapure CHR L-Proline, 4-hydroxy-, trans- (9CI) L-trans-4-Hydroxy-L-proline Dec-2t-en-4,6-diin-1-ol EINECS 200-091-9 rans-4-Hydroxy-L-proline L-HYDROXY PROLINE/TRANS-L-4-HYDROXYPROLINE TRANS-L-HYDROXYPROLINE, (2S,4R)-(-)-4-HYDROXY-2-PYRROLINECBOXYLIC ACID 4-hydroxy-L-proline (trans) (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid trans-4-Hydroxy-L-proline Vetec(TM) ade 4-Hydroxy-2-pyrrolidinecarboxylic acid (trans)-4-Hydroxy-L-proline L-Proline, allo-hydroxy L-4-HYDROXYPROLINE (4R)-4-Hydroxy-L-proline (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid,Hyp 4-Hydroxyproline L(-)-Hydroxy-4 proline D-Proline, 4-hydroxy-, cis (2S,4R)-4-hydroxypyrrolidinium-2-carboxylate Hydroxyproline HPDR1 L-Proline, 4-hydro L-4-TRANS-HYDROXYPROLINE trans-Lachnophyllol HYDROXYPROLINE, L trans-4-hydroxyproline (2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid HYDROXY-L-PROLINE, TRANS-4 trans-4-Hydroxy-L-proline L-threo-4-hydroxyproline L-trans-4-hydroxyproline L-Proline, 4-hydroxy-, (4R) allo-L-Hydroxyproline H-L-HYDROXYPROLINE OH-pro L-4-HYDROXY-2-PYRROLIDINE-CBOXYLIC ACID TRANS-ISOMER H-L-HYP-OH TRANS-4-HYDROXY-L-PROLINE (MICROBIAL & Proline, 4-allo-hydroxy-, L H-HYP-OH (TRANS) (-)-(2S,4R)-4-HYDROXYPROLINE (2S,4R)-4-hydroxyproline L-(-)-4-HYDROXYPYRROLIDINE-2-CBOXYLIC ACID (2S,4R)-4-Hydroxypyrrolidine-2-cboxylic acidHyp L-Hydroxyproline AJI92 L-Proline, 4-hydroxy-, cis L4-4-HYDROXY-2-PYRROLIDINE-CBOXYLIC ACID TRANS ISOMER (2S,4R)-trans-4-hydroxyproline HYDROXY-L-PROLINE L-HydroxyprolineForBiochemistry L-HYDROXYPROLINE ( AKA ) TRANS 4 HYDROXY L PROLINE TRANS 4 HYDROXY L PROLINE (HYPRO)

Description	L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
Related Catalog	Natural Products >> Others Research Areas >> Others
Target	Human Endogenous Metabolite
In Vitro	L-Hydroxyproline (Trans-4-hydroxy-L-proline;Trans-Hyp) has been widely used in medicine, biochemistry, food, cosmetic and other aspects of industry. Additionally, L-Hydroxyproline has also been found in the composition of some secondary metabolites such as actinomycins and echinocandins. L-Hydroxyproline is manufactured industrially most by acid hydrolysis of mammalian collagen because of its rich amount in the collagen[1].
References	[1]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.

Density	1.4±0.1 g/cm3
Boiling Point	355.2±42.0 °C at 760 mmHg
Melting Point	273 °C (dec.)(lit.)
Molecular Formula	C₅H₉NO₃
Molecular Weight	131.130
Flash Point	168.6±27.9 °C
Exact Mass	131.058243
PSA	69.56000
LogP	-1.84
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.540
Water Solubility	357.8 g/L (20 º C)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TW3586500

CHEMICAL NAME :: Proline, 4-hydroxy-, L-

CAS REGISTRY NUMBER :: 51-35-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TW3586500
HS Code	2933990090

Precursor 9
147-85-3 90600-20-7 104241-30-7 104241-32-9
104241-31-8 97652-00-1 618-28-0 74844-91-0
232262-82-7
DownStream 10
107484-30-0 107484-31-1 33265-60-0 473806-21-2
33996-30-4 4310-42-3 364750-80-1 194163-91-2
487048-28-2 32563-24-9

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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