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55511-44-9

55511-44-9 structure
55511-44-9 structure
  • Name: D-Aminoglutethimide
  • Chemical Name: (R)-aminoglutethimide
  • CAS Number: 55511-44-9
  • Molecular Formula: C13H16N2O2
  • Molecular Weight: 232.27800
  • Catalog: Research Areas Cancer
  • Create Date: 2018-09-17 16:09:09
  • Modify Date: 2024-01-05 16:42:47
  • (R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1].
Name (R)-aminoglutethimide
Synonyms (3R)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione
Aminoglutethimide,d
MFCD03094025
Description (R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1].
Related Catalog
In Vivo (R)-(+)-Aminoglutethimide (5, 50 mg/kg; p.o.) eliminates within 48 hr into urine and feces, mostly in the form of metabolites[2]. (R)-(+)-Aminoglutethimide (1, 10, 50 mg/kg; i.p.; 60 min before training) dose not induce any significant effect in 1 and 10 mg/kg, induces a loss of retention at 50 mg/kg in day-old chicks[3].
References

[1]. Dai Sig Im, et al. Chemo-enzymatic synthesis of (R)-(+)-aminoglutethimide by kinetic resolution of (±)-4-cyano-4-phenyl-1-hexanol. Journal of Molecular Catalysis B: Enzymatic. 2003, 26:185–191.

[2]. Egger H, Bartlett F, Itterly W, Rodebaugh R, Shimanskas C. Metabolism of aminoglutethimide in the rat. Drug Metab Dispos. 1982 Jul-Aug;10(4):405-12.
Density 1.173g/cm3
Boiling Point 457.4ºC at 760 mmHg
Melting Point 115.5-119.5ºC(lit.)
Molecular Formula C13H16N2O2
Molecular Weight 232.27800
Flash Point 230.4ºC
Exact Mass 232.12100
PSA 72.19000
LogP 1.73730
Index of Refraction 1.566
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
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