D-Aminoglutethimide

Modify Date: 2024-01-05 16:42:47

D-Aminoglutethimide structure	Common Name	D-Aminoglutethimide
	CAS Number	55511-44-9	Molecular Weight	232.27800
	Density	1.173g/cm3	Boiling Point	457.4ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₆N₂O₂	Melting Point	115.5-119.5ºC(lit.)
	MSDS	USA	Flash Point	230.4ºC
	Symbol	GHS07	Signal Word	Warning

Use of D-Aminoglutethimide

(R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1].

Name	(R)-aminoglutethimide
Synonym	More Synonyms

Description	(R)-(+)-Aminoglutethimide is a potent and orally active aromatase inhibitor. (R)-(+)-Aminoglutethimide has the potential for the research of breast cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Aromatase
In Vivo	(R)-(+)-Aminoglutethimide (5, 50 mg/kg; p.o.) eliminates within 48 hr into urine and feces, mostly in the form of metabolites[2]. (R)-(+)-Aminoglutethimide (1, 10, 50 mg/kg; i.p.; 60 min before training) dose not induce any significant effect in 1 and 10 mg/kg, induces a loss of retention at 50 mg/kg in day-old chicks[3].
References	[1]. Dai Sig Im, et al. Chemo-enzymatic synthesis of (R)-(+)-aminoglutethimide by kinetic resolution of (±)-4-cyano-4-phenyl-1-hexanol. Journal of Molecular Catalysis B: Enzymatic. 2003, 26:185–191. [2]. Egger H, Bartlett F, Itterly W, Rodebaugh R, Shimanskas C. Metabolism of aminoglutethimide in the rat. Drug Metab Dispos. 1982 Jul-Aug;10(4):405-12.

Density	1.173g/cm3
Boiling Point	457.4ºC at 760 mmHg
Melting Point	115.5-119.5ºC(lit.)
Molecular Formula	C₁₃H₁₆N₂O₂
Molecular Weight	232.27800
Flash Point	230.4ºC
Exact Mass	232.12100
PSA	72.19000
LogP	1.73730
Index of Refraction	1.566

D-Aminoglutethimide MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport

Precursor 9
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(3R)-3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione

Aminoglutethimide,d

MFCD03094025

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China
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China
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