566-28-9

566-28-9 structure

Name: 7-KETOCHOLESTEROL
Chemical Name: 7-ketocholesterol
CAS Number: 566-28-9
Molecular Formula: C₂₇H₄₄O₂
Molecular Weight: 400.637
Catalog: Research Areas Metabolic Disease
Create Date: 2018-03-21 08:00:00
Modify Date: 2024-01-03 08:03:37
7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1].

Name	7-ketocholesterol
Synonyms	cholest-3,5-dien-7-one Cholest-5-en-7-one, 3-hydroxy-, (3β)- 3b-Hydroxycholest-5-en-7-one Cholesta-3,5-dien-7-on 7-KETOCHOLESTEROL 7-Ketocholesta-3,5-diene (3β)-3-Hydroxycholest-5-en-7-one 3,5-cholestadien-7-one Cholesta-3,5-diene-7-one-d7 7-oxo-3,5-cholestadiene cholesta-3,5-dien-7-one 7-oxocholesta-3,5-diene cholest-3,5-diene-7-one 7-Oxocholesterol 7-Keto Cholesterol

Description	7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
References	[1]. M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31(3-4):369-75. [2]. Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380.

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 24,1103,1986

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