7-KETOCHOLESTEROL
7-KETOCHOLESTEROL structure
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Common Name | 7-KETOCHOLESTEROL | ||
|---|---|---|---|---|
| CAS Number | 566-28-9 | Molecular Weight | 400.637 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 516.7±29.0 °C at 760 mmHg | |
| Molecular Formula | C27H44O2 | Melting Point | 158-160ºC | |
| MSDS | Chinese USA | Flash Point | 218.5±16.9 °C | |
Use of 7-KETOCHOLESTEROL7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1]. |
| Name | 7-ketocholesterol |
|---|---|
| Synonym | More Synonyms |
| Description | 7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
[1]. M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31(3-4):369-75. [2]. Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380. |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 516.7±29.0 °C at 760 mmHg |
| Melting Point | 158-160ºC |
| Molecular Formula | C27H44O2 |
| Molecular Weight | 400.637 |
| Flash Point | 218.5±16.9 °C |
| Exact Mass | 400.334137 |
| PSA | 37.30000 |
| LogP | 7.57 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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On-line liquid chromatography-gas chromatography: A novel approach for the analysis of phytosterol oxidation products in enriched foods.
J. Chromatogr. A. 1396 , 98-108, (2015) A novel methodology for the automated qualitative and quantitative determination of phytosterol oxidation products in enriched foods via on-line liquid chromatography-gas chromatography (LC-GC) was es... |
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Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.
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| cholest-3,5-dien-7-one |
| Cholest-5-en-7-one, 3-hydroxy-, (3β)- |
| 3b-Hydroxycholest-5-en-7-one |
| Cholesta-3,5-dien-7-on |
| 7-KETOCHOLESTEROL |
| 7-Ketocholesta-3,5-diene |
| (3β)-3-Hydroxycholest-5-en-7-one |
| 3,5-cholestadien-7-one |
| Cholesta-3,5-diene-7-one-d7 |
| 7-oxo-3,5-cholestadiene |
| cholesta-3,5-dien-7-one |
| 7-oxocholesta-3,5-diene |
| cholest-3,5-diene-7-one |
| 7-Oxocholesterol |
| 7-Keto Cholesterol |