7-KETOCHOLESTEROL
Modify Date: 2026-07-07 18:27:53
7-KETOCHOLESTEROL structure
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Common Name | 7-KETOCHOLESTEROL | ||
|---|---|---|---|---|
| CAS Number | 566-28-9 | Molecular Weight | 400.637 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 516.7±29.0 °C at 760 mmHg | |
| Molecular Formula | C27H44O2 | Melting Point | 158-160ºC | |
| MSDS | Chinese USA | Flash Point | 218.5±16.9 °C | |
Use of 7-KETOCHOLESTEROL7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1]. |
| Name | 7-ketocholesterol |
|---|---|
| Synonym | More Synonyms |
| Description | 7-Ketocholesterol, toxic oxysterol, inhibits the rate-limiting step in bile acid biosynthesis cholesterol 7 alpha-hydroxylase, as well as strongly inhibiting HMG-CoA reductase (the rate-limiting enzyme in cholesterol biosynthesis). 7-Ketocholesterol induces cell apoptosis[1]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| References |
[1]. M A Lyons, et al. 7-Ketocholesterol. Int J Biochem Cell Biol. Mar-Apr 1999;31(3-4):369-75. [2]. Amelia Anderson, et al. 7-Ketocholesterol in disease and aging. Redox Biol. 2020 Jan;29:101380. |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 516.7±29.0 °C at 760 mmHg |
| Melting Point | 158-160ºC |
| Molecular Formula | C27H44O2 |
| Molecular Weight | 400.637 |
| Flash Point | 218.5±16.9 °C |
| Exact Mass | 400.334137 |
| PSA | 37.30000 |
| LogP | 7.57 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| InChIKey | YIKKMWSQVKJCOP-ABXCMAEBSA-N |
| SMILES | CC(C)CCCC(C)C1CCC2C3C(=O)C=C4CC(O)CCC4(C)C3CCC12C |
| Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.
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Name: Primary cell-based high-throughput screening assay for identification of compounds th...
Source: Johns Hopkins Ion Channel Center
Target: regulator of G-protein signaling 4 isoform 2 [Homo sapiens]
External Id: JHICC_RGS_Act_HTS
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Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN
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|
Name: QFRET-based biochemical primary high throughput screening assay to identify exosite i...
Source: The Scripps Research Institute Molecular Screening Center
Target: disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens]
External Id: ADAM17_INH_QFRET_1536_1X%INH PRUN
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Name: ERK5 transcriptional activity HTS
Source: 24565
Target: N/A
External Id: ERK5 transcriptional activity-HTS
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Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN
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|
Name: uHTS identification of small molecule activators of the adaptive arm of the Unfolded ...
Source: Burnham Center for Chemical Genomics
Target: N/A
External Id: BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay
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Name: Fluorescence polarization to screen for inhibitor that competite the binding of FadD2...
Source: Broad Institute
Target: FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE)
External Id: 2147-01_Inhibitor_SinglePoint_HTS_Activity
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|
Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN
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|
Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN
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Name: Absorbance-based primary biochemical high throughput screening assay to identify acti...
Source: The Scripps Research Institute Molecular Screening Center
Target: caspase-3 preproprotein [Homo sapiens]
External Id: PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN
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| cholest-3,5-dien-7-one |
| 3b-Hydroxycholest-5-en-7-one |
| Cholesta-3,5-dien-7-on |
| 7-KETOCHOLESTEROL |
| 7-Ketocholesta-3,5-diene |
| (3β)-3-Hydroxycholest-5-en-7-one |
| 3,5-cholestadien-7-one |
| Cholesta-3,5-diene-7-one-d7 |
| 7-oxo-3,5-cholestadiene |
| cholesta-3,5-dien-7-one |
| 7-oxocholesta-3,5-diene |
| cholest-3,5-diene-7-one |
| 7-Oxocholesterol |
| 7-Keto Cholesterol |