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126519-80-0

126519-80-0 structure
126519-80-0 structure
  • Name: OTs-C6-OBn
  • Chemical Name: 4-methylbenzenesulfonic acid,6-phenylmethoxyhexan-1-ol
  • CAS Number: 126519-80-0
  • Molecular Formula: C20H26O4S
  • Molecular Weight: 380.49800
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-10-16 12:41:31
  • Modify Date: 2024-01-08 12:24:37
  • OTs-C6-OBn is a PROTAC linker, which refers to the alkyl chain composition. OTs-C6-OBn can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878)[1].
Name 4-methylbenzenesulfonic acid,6-phenylmethoxyhexan-1-ol
Synonyms 6-benzyloxy-1-hexyl 4-toluenesulfonate
6-benzyloxyhexyl tosylate
6-benzyloxyhexyl 4-methylbenzenesulfonate
Description OTs-C6-OBn is a PROTAC linker, which refers to the alkyl chain composition. OTs-C6-OBn can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878)[1].
Related Catalog
Target

Alkyl-Chain
In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
Molecular Formula C20H26O4S
Molecular Weight 380.49800
Exact Mass 380.16600
PSA 92.21000
LogP 5.07840
Hazard Codes Xi
78132-75-9 structure

78132-75-9
98-59-9 structure

98-59-9

~82%

126519-80-0 structure

126519-80-0
Literature: Liu, Peng; Xu, Xing; Chen, Lili; Ma, Lei; Shen, Xu; Hu, Lihong Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1596 - 1607
71126-73-3 structure

71126-73-3
98-59-9 structure

98-59-9

~97%

126519-80-0 structure

126519-80-0
Literature: Colera, Manuel; Costero, Ana M.; Gavina, Pablo; Gil, Salvador Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2673 - 2679
629-11-8 structure

629-11-8

~%

126519-80-0 structure

126519-80-0
Literature: Mori, Kenji; Qian, Zhao-Hui Liebigs Annalen der Chemie, 1994 , # 3 p. 291 - 296
100-39-0 structure

100-39-0

~%

126519-80-0 structure

126519-80-0
Literature: Matsumoto, Kazutsugu; Shimojo, Megumi; Hatanaka, Minoru Chemistry Letters, 1997 , # 11 p. 1151 - 1152
100-44-7 structure

100-44-7

~%

126519-80-0 structure

126519-80-0
Literature: Shikichi, Yasumasa; Mori, Kenji Bioscience, Biotechnology and Biochemistry, 2012 , vol. 76, # 10 p. 1943 - 1951
502-44-3 structure

502-44-3

~%

126519-80-0 structure

126519-80-0
Literature: Liu, Peng; Xu, Xing; Chen, Lili; Ma, Lei; Shen, Xu; Hu, Lihong Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1596 - 1607
4547-43-7 structure

4547-43-7

~%

126519-80-0 structure

126519-80-0
Literature: Liu, Peng; Xu, Xing; Chen, Lili; Ma, Lei; Shen, Xu; Hu, Lihong Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1596 - 1607

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title: CAS No. 126519-80-0 | Chemsrc address: https://m.chemsrc.com/en/baike/778969.html

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