OTs-C6-OBn

Modify Date: 2024-01-08 12:24:37

OTs-C6-OBn Structure
OTs-C6-OBn structure
 Common Name OTs-C6-OBn
CAS Number 126519-80-0 Molecular Weight 380.49800
Density N/A Boiling Point N/A
Molecular Formula C20H26O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of OTs-C6-OBn


OTs-C6-OBn is a PROTAC linker, which refers to the alkyl chain composition. OTs-C6-OBn can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878)[1].

 Names

Name 4-methylbenzenesulfonic acid,6-phenylmethoxyhexan-1-ol
Synonym More Synonyms

 OTs-C6-OBn Biological Activity

Description OTs-C6-OBn is a PROTAC linker, which refers to the alkyl chain composition. OTs-C6-OBn can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878)[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.

 Chemical & Physical Properties

Molecular Formula C20H26O4S
Molecular Weight 380.49800
Exact Mass 380.16600
PSA 92.21000
LogP 5.07840

 Safety Information

Hazard Codes Xi

 Synthetic Route

benzyl 5-methoxycarbonylpentyl ether structure

benzyl 5-methox...

CAS#:78132-75-9

Tosyl chloride structure

Tosyl chloride

CAS#:98-59-9

~82%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Liu, Peng; Xu, Xing; Chen, Lili; Ma, Lei; Shen, Xu; Hu, Lihong Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1596 - 1607
6-(Benzyloxy)hexan-1-ol structure

6-(Benzyloxy)he...

CAS#:71126-73-3

Tosyl chloride structure

Tosyl chloride

CAS#:98-59-9

~97%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Colera, Manuel; Costero, Ana M.; Gavina, Pablo; Gil, Salvador Tetrahedron Asymmetry, 2005 , vol. 16, # 15 p. 2673 - 2679
Hexan-1,6-diol structure

Hexan-1,6-diol

CAS#:629-11-8

~%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Mori, Kenji; Qian, Zhao-Hui Liebigs Annalen der Chemie, 1994 , # 3 p. 291 - 296
Benzyl bromide structure

Benzyl bromide

CAS#:100-39-0

~%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Matsumoto, Kazutsugu; Shimojo, Megumi; Hatanaka, Minoru Chemistry Letters, 1997 , # 11 p. 1151 - 1152
Benzyl chloride structure

Benzyl chloride

CAS#:100-44-7

~%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Shikichi, Yasumasa; Mori, Kenji Bioscience, Biotechnology and Biochemistry, 2012 , vol. 76, # 10 p. 1943 - 1951
6-Hexanolactone structure

6-Hexanolactone

CAS#:502-44-3

~%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Liu, Peng; Xu, Xing; Chen, Lili; Ma, Lei; Shen, Xu; Hu, Lihong Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1596 - 1607
6-hydroxyhexanoic acid methyl ester structure

6-hydroxyhexano...

CAS#:4547-43-7

~%

OTs-C6-OBn Structure

OTs-C6-OBn

CAS#:126519-80-0

Literature: Liu, Peng; Xu, Xing; Chen, Lili; Ma, Lei; Shen, Xu; Hu, Lihong Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 5 p. 1596 - 1607

 Synonyms

6-benzyloxy-1-hexyl 4-toluenesulfonate
6-benzyloxyhexyl tosylate
6-benzyloxyhexyl 4-methylbenzenesulfonate
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Related Compounds: More...
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51857-17-1
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1384870-47-6
Chemsrc provides OTs-C6-OBn(CAS#:126519-80-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of OTs-C6-OBn are included as well.>> amp version: OTs-C6-OBn

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