Name | 1,3-Dibromo-5,5-dimethylhydantoin |
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Synonyms |
N,N'-dibromo-5,5-dimethyl hydantoin
1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione 2,4-Imidazolidinedione, 1,3-dibromo-5,5-dimethyl- DIBROMANTIN 3-DibroMo-5 DDH 1,3-dibromo-5,5-dimethyl-hydantoin 1,3-Dibromo-5,5-dimethyl-2,4-imidazolidinedione 1,3-Dibromo-5,5-dimethyl hydantoin EINECS 201-030-9 1,3-Dibromo-5,5-dimethylhydantoin Bromotoin dibromantine BROMTOIN DIBROMATIN 1,3-Dibromo-5 DBDMH 1,3-dibromo-4,4-dimethyl-2,5-dioxoimidazolidine MFCD00003189 |
Description | 1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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Related Catalog | |
Target |
Alkyl-Chain |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
Density | 2.2±0.1 g/cm3 |
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Boiling Point | 250.2±23.0 °C at 760 mmHg |
Melting Point | 197-199 °C (dec.)(lit.) |
Molecular Formula | C5H6Br2N2O2 |
Molecular Weight | 285.921 |
Flash Point | 105.1±22.6 °C |
Exact Mass | 283.879578 |
PSA | 40.62000 |
LogP | 1.68 |
Vapour Pressure | 0.0±0.5 mmHg at 25°C |
Index of Refraction | 1.622 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS03, GHS05, GHS06, GHS09 |
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Signal Word | Danger |
Hazard Statements | H272-H301-H314-H317-H410 |
Precautionary Statements | Missing Phrase - N15.00950417-P210-P220-P280-P305 + P351 + P338-P370 + P378 |
Personal Protective Equipment | Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
Hazard Codes | C:Corrosive |
Risk Phrases | R22;R34;R50;R8 |
Safety Phrases | S17-S26-S36/37/39-S45-S60-S61 |
RIDADR | UN 3087 5.1/PG 2 |
WGK Germany | 3 |
RTECS | MU0686000 |
Packaging Group | II |
Hazard Class | 5.1 |
HS Code | 29332100 |
~99% 77-48-5 |
Literature: ALBEMARLE CORPORATION Patent: EP1250045 B1, 2003 ; |
~% 77-48-5 |
Literature: US2868787 , ; |
~% 77-48-5 |
Literature: Anales de la Asociacion Quimica Argentina (1921-2001), , vol. 41, p. 153 |
Precursor 4 | |
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DownStream 10 | |
HS Code | 2933990090 |
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Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |