Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

222638-67-7

222638-67-7 structure

Name: BEC hydrochloride
Chemical Name: s-(2-boronoethyl)-l-cysteine hydrochloride
CAS Number: 222638-67-7
Molecular Formula: C₅H₁₃BClNO₄S
Molecular Weight: 229.49000
Catalog: Research Areas Cancer
Create Date: 2017-10-29 22:57:49
Modify Date: 2026-06-30 09:59:24
BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).target: Arginase II [1];In vitro: BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]

Name	s-(2-boronoethyl)-l-cysteine hydrochloride
Synonyms	S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE BEC hydrochloride, 10 mM in DMSO BEC HCl a slow-binding and competitive ginase II inhibitor Reaxys ID Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,ginase,BEC,BEC hydrochloride,ginase-II,inflammation,CCL20 BEC HCl Methionine Impurity 19 BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride (R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride Methsuximide Impurity 1(Normesuximide)

Description	BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).target: Arginase II [1];In vitro: BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Arginase Research Areas >> Cancer
References	[1]. Colleluori DM et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62. [2]. Kim NN et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. [3]. Karina Ckless et al. Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration. J Immunol. Author manuscript; available in PMC 2010 Jun 28. [4]. Steppan J et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64.

Molecular Formula	C₅H₁₃BClNO₄S
Molecular Weight	229.49000
Exact Mass	229.03500
PSA	129.08000
LogP	0.10660
Storage condition	-20℃

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

1354222-15-3	823189-17-9
1111832-69-9	1486086-94-5
1488791-28-1	876028-76-1
1536861-98-9	1369934-00-8
1493606-06-6	1497315-37-3