222638-67-7
222638-67-7 structure
- Name: BEC hydrochloride
- Chemical Name: s-(2-boronoethyl)-l-cysteine hydrochloride
- CAS Number: 222638-67-7
- Molecular Formula: C5H13BClNO4S
- Molecular Weight: 229.49000
- Catalog: Research Areas Cancer
- Create Date: 2017-10-29 22:57:49
- Modify Date: 2024-01-02 08:38:29
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BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).target: Arginase II [1];In vitro: BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4]
| Name | s-(2-boronoethyl)-l-cysteine hydrochloride |
|---|---|
| Synonyms |
BEC HCl
BEC hydrochloride |
| Description | BEC HCl is a slow-binding and competitive Arginase II inhibitor with Ki of 0.31 μM (ph 7.5).target: Arginase II [1];In vitro: BEC HCl causes significant enhancement of NO-dependent smooth muscle relaxation in this tissue. [2] BEC HCl enhances perivascular and peribronchiolar lung inflammation, mucus metaplasia, NF-κB DNA binding, and mRNA expression of the NF-κB-driven chemokine genes CCL20 and KC, and lead to further increases in airways hyperresponsiveness. [3] In vivo: BEC HCl increased contractility in isolated myocytes from WT and NOS3 but not NOS1 knockout mice. [4] |
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| Related Catalog | |
| References |
| Molecular Formula | C5H13BClNO4S |
|---|---|
| Molecular Weight | 229.49000 |
| Exact Mass | 229.03500 |
| PSA | 129.08000 |
| LogP | 0.10660 |
| Storage condition | -20℃ |