222638-67-7

222638-67-7结构式

中文名	BEC盐酸盐
英文名	s-(2-boronoethyl)-l-cysteine hydrochloride
中文别名	(R)-2-氨基-3-((2-硼酸乙基)硫代)丙酸盐酸盐 BEC HCL, 一个竞争性的 GINASE II抑制剂甲硫氨酸杂质19 BEC HCl 试剂 S-(2-硼酸基乙基)-L-半胱氨酸盐酸盐
英文别名	S-(2-BORONOETHYL)-L-CYSTEINE HYDROCHLORIDE BEC hydrochloride, 10 mM in DMSO BEC HCl a slow-binding and competitive ginase II inhibitor Reaxys ID Inhibitor,NF-κB,hyperresponsiveness,metaplasia,inhibit,ginase,BEC,BEC hydrochloride,ginase-II,inflammation,CCL20 BEC HCl Methionine Impurity 19 BEC hydrochloride - S-(2-Boronoethyl)-L-cysteine hydrochloride (R)-2-amino-3-((2-boronoethyl)thio)propanoic acid hydrochloride Methsuximide Impurity 1(Normesuximide)

描述	BEC HCl是一个竞争性的 Arginase II抑制剂,Ki值是0.31 uM (ph 7.5).
相关类别	信号通路 >> 免疫及炎症 >> 精氨酸研究领域 >> 癌症
参考文献	[1]. Colleluori DM et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62. [2]. Kim NN et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88. [3]. Karina Ckless et al. Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration. J Immunol. Author manuscript; available in PMC 2010 Jun 28. [4]. Steppan J et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64.