222638-67-7

• 常用中文名：BEC盐酸盐
• 常用英文名：BEC hydrochloride
• CAS号：222638-67-7
• 分子式：C₅H₁₃BClNO₄S
• 分子量：229.49000
• 相关类别： 研究领域 癌症
• 发布时间：2017-10-29 22:57:49
• 更新时间：2024-01-02 08:38:29
• BEC HCl是一个竞争性的 Arginase II抑制剂，Ki值是0.31 uM (ph 7.5).

名称

• 中文名: BEC盐酸盐
• 英文名: s-(2-boronoethyl)-l-cysteine hydrochloride
• 英文别名: BEC HCl; BEC hydrochloride

物化性质

• 分子式: C₅H₁₃BClNO₄S
• 分子量: 229.49000
• 精确质量: 229.03500
• PSA: 129.08000
• LogP: 0.10660
• 外观性状: 粉末
• 储存条件: -20℃

生物活性

• 描述: BEC HCl是一个竞争性的 Arginase II抑制剂,Ki值是0.31 uM (ph 7.5).
• 相关类别:
  信号通路 >> 免疫及炎症 >> 精氨酸
  研究领域 >> 癌症
• 参考文献:

  [1]. Colleluori DM et al. Classical and slow-binding inhibitors of human type II arginase. Biochemistry. 2001 Aug 7;40(31):9356-62.

  [2]. Kim NN et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry. 2001 Mar 6;40(9):2678-88.

  [3]. Karina Ckless et al. Inhibition of Arginase Activity Enhances Inflammation in Mice with Allergic Airway Disease, in Association with Increases in Protein S-Nitrosylation and Tyrosine Nitration. J Immunol. Author manuscript; available in PMC 2010 Jun 28.

  [4]. Steppan J et al. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64.