134612-80-9

134612-80-9 structure

Name: 3-O-Methyl Tolcapone
Chemical Name: 3-O-Methyl Tolcapone
CAS Number: 134612-80-9
Molecular Formula: C₁₅H₁₃NO₅
Molecular Weight: 315.32100
Catalog: Signaling Pathways Metabolic Enzyme/Protease COMT
Create Date: 2018-12-28 18:09:46
Modify Date: 2024-01-03 07:48:13
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].

Name	3-O-Methyl Tolcapone
Synonyms	1-(4-Hydroxy-3-methoxy-5-nitrophenyl)-3-(p-tolyl)propan-2-one (4-hydroxy-3-methoxy-5-nitrophenyl)-(4-methylphenyl)methanone

Description	3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> COMT Research Areas >> Neurological Disease Signaling Pathways >> Metabolic Enzyme/Protease >> COMT
Target	COMT[1][2]
References	[1]. Jorga K, et al. Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase. Br J Clin Pharmacol. 1999 Oct;48(4):513-20. [2]. Ceravolo R, et al. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease. Synapse. 2002 Mar 1;43(3):201-7.

Hazard Codes	Xi
RIDADR	NONH for all modes of transport
HS Code	2914700090

93899-23-1

134612-80-9

Literature: US5236952 A1, ;

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%