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1404-64-4

1404-64-4 structure
1404-64-4 structure
  • Name: Sparsomycin
  • Chemical Name: sparsomycin
  • CAS Number: 1404-64-4
  • Molecular Formula: C13H19N3O5S2
  • Molecular Weight: 361.44
  • Create Date: 2018-07-23 19:11:06
  • Modify Date: 2024-01-14 18:07:09
  • Sparsomycin is a metabolite of the bacterium Streptomyces sparsogenes. Sparsomycin inhibits protein synthesis in both eukaryotic cells and bacteria. Sparsomycin inhibits the translation extension of ribosome PTC[1].

Name sparsomycin
Synonyms Sparsomycin from Streptomyces sparsogenes
sparsamycin
Description Sparsomycin is a metabolite of the bacterium Streptomyces sparsogenes. Sparsomycin inhibits protein synthesis in both eukaryotic cells and bacteria. Sparsomycin inhibits the translation extension of ribosome PTC[1].
Related Catalog
References

[1]. Codjo H, et, al. COVID-19: Mechanisms of the Antiviral Activities of Selective Antibiotics Targeting the Human 80S Ribosome. 2021;15:38-52.

[2]. Lazaro E, et, al. Interaction of the antibiotic sparsomycin with the ribosome. Antimicrob Agents Chemother. 1991 Jan;35(1):10-3.  

Density 1.466g/cm3
Molecular Formula C13H19N3O5S2
Molecular Weight 361.44
Exact Mass 361.07700
PSA 176.63000
LogP 0.18770
Index of Refraction 1.656

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG5850000
CHEMICAL NAME :
Sparsomycin
CAS REGISTRY NUMBER :
1404-64-4
LAST UPDATED :
199504
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C13-H19-N3-O5-S2
MOLECULAR WEIGHT :
361.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
DNA adduct
TEST SYSTEM :
Bacteria - Escherichia coli
DOSE/DURATION :
20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973
Hazard Codes T+: Very toxic;
Risk Phrases 28
Safety Phrases 28-36/37-45
RIDADR UN 2811 6.1/PG 2