138-56-7
138-56-7 structure
- Name: Trimethobenzamide
- Chemical Name: N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
- CAS Number: 138-56-7
- Molecular Formula: C21H28N2O5
- Molecular Weight: 388.45700
- Catalog: API Digestive system medication Antiemetic emetic
- Create Date: 2018-08-26 18:34:13
- Modify Date: 2024-01-03 16:46:15
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Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1].
| Name | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide |
|---|---|
| Synonyms |
Tebamide
Trimethobenzamid EINECS 205-332-1 Trimethobenzamidum Trimazide Benzacot trimethobenzamide Tribenzagan Tigan Stemetic Trimetobenzamida |
| Description | Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. |
|---|---|
| Related Catalog | |
| Target |
D2 receptor[1] |
| In Vitro | Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1]. |
| In Vivo | The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1]. |
| References |
[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42. |
| Density | 1.131 g/cm3 |
|---|---|
| Boiling Point | 506.9ºC at 760 mmHg |
| Molecular Formula | C21H28N2O5 |
| Molecular Weight | 388.45700 |
| Flash Point | 260.4ºC |
| Exact Mass | 388.20000 |
| PSA | 69.26000 |
| LogP | 2.97370 |
| Vapour Pressure | 2.13E-10mmHg at 25°C |
| Hazard Codes | Xi |
|---|---|
| HS Code | 2924299090 |
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| Literature: US2879293 , ; |
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| Literature: US2879293 , ; |
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| Literature: US2879293 , ; |
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| Literature: Chemical and Pharmaceutical Bulletin, , vol. 40, # 1 p. 202 - 211 |
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| Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
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| Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
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| Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |