Trimethobenzamide structure
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Common Name | Trimethobenzamide | ||
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CAS Number | 138-56-7 | Molecular Weight | 388.45700 | |
Density | 1.131 g/cm3 | Boiling Point | 506.9ºC at 760 mmHg | |
Molecular Formula | C21H28N2O5 | Melting Point | N/A | |
MSDS | N/A | Flash Point | 260.4ºC |
Use of TrimethobenzamideTrimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. |
Name | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide |
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Synonym | More Synonyms |
Description | Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1]. |
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Related Catalog | |
Target |
D2 receptor[1] |
In Vitro | Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1]. |
In Vivo | The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1]. |
References |
[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42. |
Density | 1.131 g/cm3 |
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Boiling Point | 506.9ºC at 760 mmHg |
Molecular Formula | C21H28N2O5 |
Molecular Weight | 388.45700 |
Flash Point | 260.4ºC |
Exact Mass | 388.20000 |
PSA | 69.26000 |
LogP | 2.97370 |
Vapour Pressure | 2.13E-10mmHg at 25°C |
Hazard Codes | Xi |
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HS Code | 2924299090 |
~% Trimethobenzamide CAS#:138-56-7 |
Literature: US2879293 , ; |
~% Trimethobenzamide CAS#:138-56-7 |
Literature: US2879293 , ; |
~% Trimethobenzamide CAS#:138-56-7 |
Literature: US2879293 , ; |
~% Trimethobenzamide CAS#:138-56-7 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 40, # 1 p. 202 - 211 |
~% Trimethobenzamide CAS#:138-56-7 |
Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
~% Trimethobenzamide CAS#:138-56-7 |
Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
~0% Trimethobenzamide CAS#:138-56-7
Detail
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Literature: Organic Process Research and Development, , vol. 17, # 7 p. 981 - 984 |
HS Code | 2924299090 |
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Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Tebamide |
Trimethobenzamid |
EINECS 205-332-1 |
Trimethobenzamidum |
Trimazide |
Benzacot |
trimethobenzamide |
Tribenzagan |
Tigan |
Stemetic |
Trimetobenzamida |