Trimethobenzamide

Modify Date: 2024-01-03 16:46:15

Trimethobenzamide Structure
Trimethobenzamide structure
Common Name Trimethobenzamide
CAS Number 138-56-7 Molecular Weight 388.45700
Density 1.131 g/cm3 Boiling Point 506.9ºC at 760 mmHg
Molecular Formula C21H28N2O5 Melting Point N/A
MSDS N/A Flash Point 260.4ºC

 Use of Trimethobenzamide


Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1].

 Names

Name N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4,5-trimethoxybenzamide
Synonym More Synonyms

 Trimethobenzamide Biological Activity

Description Trimethobenzamide (Ro 2-9578 free base) is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting[1].
Related Catalog
Target

D2 receptor[1]

In Vitro Trimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center[1].
In Vivo The oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration[1].
References

[1]. Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.

 Chemical & Physical Properties

Density 1.131 g/cm3
Boiling Point 506.9ºC at 760 mmHg
Molecular Formula C21H28N2O5
Molecular Weight 388.45700
Flash Point 260.4ºC
Exact Mass 388.20000
PSA 69.26000
LogP 2.97370
Vapour Pressure 2.13E-10mmHg at 25°C

 Safety Information

Hazard Codes Xi
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Tebamide
Trimethobenzamid
EINECS 205-332-1
Trimethobenzamidum
Trimazide
Benzacot
trimethobenzamide
Tribenzagan
Tigan
Stemetic
Trimetobenzamida