1007117-62-5

1007117-62-5 structure

Name: CMP-Sialic acid sodium salt
Chemical Name: CMP-β-Neu5Ac
CAS Number: 1007117-62-5
Molecular Formula: C₂₀H₃₀N₄NaO₁₆P
Molecular Weight: 636.433
Catalog: Research Areas Metabolic Disease
Create Date: 2017-12-07 11:56:33
Modify Date: 2024-01-29 15:13:18
CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases[1].

Name	CMP-β-Neu5Ac
Synonyms	CMP-Sialic Acid (sodium salt) cytidine-5''-monophospho-N-acetylneuraminic acid sodium salt CMP-Neu5Ac CMP-NeuAc CMP-NANA Sodium (2R,4S,5R,6R)-5-acetamido-2-{[{[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(hydroxy)phosphoryl]oxy}-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate

Description	CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	CMP-Sialic acid (CMP-Neu5Ac), the activated form of Neu5Ac, serves as the common activated sugar donor for all the sialyltransferases to transfer a single sialic acid to an acceptor or a growing oligosaccharide chain. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[2].
References	[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.