CMP-Sialic acid sodium salt

Modify Date: 2024-01-29 15:13:18

CMP-Sialic acid sodium salt Structure
CMP-Sialic acid sodium salt structure
Common Name CMP-Sialic acid sodium salt
CAS Number 1007117-62-5 Molecular Weight 636.433
Density N/A Boiling Point N/A
Molecular Formula C20H30N4NaO16P Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CMP-Sialic acid sodium salt


CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases[1].

 Names

Name CMP-β-Neu5Ac
Synonym More Synonyms

 CMP-Sialic acid sodium salt Biological Activity

Description CMP-Sialic acid sodium salt (CMP-Neu5Ac sodium salt) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase, the enzyme that initiates sialic acid synthesis. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases[1].
Related Catalog
In Vitro CMP-Sialic acid (CMP-Neu5Ac), the activated form of Neu5Ac, serves as the common activated sugar donor for all the sialyltransferases to transfer a single sialic acid to an acceptor or a growing oligosaccharide chain. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[2].
References

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5.

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

 Chemical & Physical Properties

Molecular Formula C20H30N4NaO16P
Molecular Weight 636.433
Exact Mass 636.129211
PSA 335.55000

 Synonyms

CMP-Sialic Acid (sodium salt)
cytidine-5''-monophospho-N-acetylneuraminic acid sodium salt
CMP-Neu5Ac
CMP-NeuAc
CMP-NANA
Sodium (2R,4S,5R,6R)-5-acetamido-2-{[{[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1(2H)-pyrimidinyl)-3,4-dihydroxytetrahydro-2-furanyl]methoxy}(hydroxy)phosphoryl]oxy}-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]tetrahydro-2H-pyran-2-carboxylate