332371-82-1

332371-82-1 structure

Name: 1,7-Bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
Chemical Name: 1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
CAS Number: 332371-82-1
Molecular Formula: C₁₉H₁₈O₃
Molecular Weight: 294.34
Catalog: Natural product Phenols
Create Date: 2016-10-17 12:13:33
Modify Date: 2024-01-04 21:09:28
1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].

Name	1,7-bis(4-hydroxyphenyl)hepta-4,6-dien-3-one
Synonyms	4,6-Heptadien-3-one, 1,7-bis(4-hydroxyphenyl)-, (4E,6E)- (4E,6E)-1,7-Bis(4-hydroxyphenyl)-4,6-heptadien-3-one

Description	1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 6) shows antiproliferative activity with ED50s of 57.7, 78.8 µM for 26-L5 and HT-1080 cells, respectively. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one inhibits melanogenesis in B16 melanoma 4A5 cells. 1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one has the potential for the research of skin disorders[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	1,7-Bis(4-hydroxyphenyl)-hepta-4E,6E-dien-3-one (compound 2) (1-10 µM) inhibits melanogenesis in B16 melanoma 4A5 cells with an IC50 of 1.99 µM[2].
References	[1]. Ali MS, et al. Six new diarylheptanoids from the seeds of Alpinia blepharocalyx. J Nat Prod. 2001 Mar;64(3):289-93. [2]. Matsumoto T, et al. Diarylheptanoids with inhibitory effects on melanogenesis from the rhizomes of Curcuma comosa in B16 melanoma cells. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5178-81.

Hazard Codes	Xi