24305-27-9
24305-27-9 structure
- Name: TRH
- Chemical Name: protirelin
- CAS Number: 24305-27-9
- Molecular Formula: C16H22N6O4
- Molecular Weight: 362.38
- Catalog: API Hormone and endocrine-regulating drugs Thyroid hormone and antithyroid drugs
- Create Date: 2018-08-20 22:11:47
- Modify Date: 2026-07-03 12:04:15
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Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions.
| Name | protirelin |
|---|---|
| Synonyms |
thyrotropin-releasing hormone
fda1725 PYR-HIS-PRO-NH2(TRH) rifathyroin TRH (Thyrotropin Releasing Hormone) 5-Oxo-L-prolyl-L-histidyl-L-proline TRF hTRF1-AS PGLU-HIS-PRO AMIDE ACETATE F & D VERSIO PYR-HIS-PRO-NH2 <Glu-His-Pro-NH2 Thypinone TRF1 TRF,TRH pglu-his-pro amide acetate L-PYROGLUTAMYL-L-HISTIDYL-L-PROLINAMIDE l-pyroglutamyl-l-histidyl-l-prolineamide Anti-Telomeric Reat Binding Factor 1 antibody produced in rabbit Thyrotropin-releasing horMone Acetate Stimu TSH L-pyroglutamyl-L-histidyl-L-proline amide lopremone thyrotropic-releasingfactor MFCD00038640 thyroidreleasinghormone THYROTROPIN RELEASING HORMONE Monoclonal Anti-TERF1 antibody produced in mouse ro8-6270/9 TERF1 pGlu-His-Pro amide, Thyroliberin, TRF, TRH, L-Pyroglutamyl-L-histidyl-L-prolinamide 5-oxo-l-prolyl-l-histidyl-l-prolinamid THR 1-2 1-(N-(5-Oxo-L-prolyl)-L-histidyl)-L-proline EINECS 246-143-4 Glp-His-Pro-NH2 Pyr-HP-NH2 THYROTROPIN RELEASING HORMONE ACETATE TE pGlu-His-Pro-NH2 NIMA-interacting protein 2 PROTIRELIN ANTI-TRF (TERF1)(C-TERMINAL) antibody produced in rabbit Prolactoliberin, Prolactostatin, Protirelin, Thyroliberin pglu-his-pro amide free base H-PGLU-HIS-PRO-NH2 PGLU-HIS-PRO-NH2 tsh-rf (2S)-N-[(2S)-1-[(2S)-2-Cbamoylpyrrolidin-1-yl]-3-(1H-imidazol-2-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-cboxamide synthetictsh-releasingfactor Thyrotropin releasing hormone,L-Pyroglutamyl-L-histidyl-L-prolinamide, TRF, TRH, Thyroliberin, pGlu-His-Pro amide Thyrotropin releasing hormone (TRH) TRH, Thyroliberin PYROGLU-HIS-PRO NH2 PGLU-HIS-PRO AMIDE TRBF1 tsh-releasingfactor synthetictrh Prem synthetictrf THR 2-3 GLP-HIS-PRO-NH2 THYROLIBERIN L-pGlu-L-His-L-ProNH2 PYROGLU-HIS-PRO AMIDE t-TRF1 thyrotrophin-releasing hormone TTAGGG reat binding factor 1 GLP-HIS-PRO-NH2: GLP-HP-NH2 PIN2 tsh-releasinghormone thyrotropin-releasingfactor synthetictsh-releasinghormone |
| Description | Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. |
|---|---|
| Related Catalog | |
| Target |
Thyroid hormone receptor |
| In Vivo | Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction[1]. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin[2]. |
| Animal Admin | Rats[2] Ninety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 942.1±65.0 °C at 760 mmHg |
| Molecular Formula | C16H22N6O4 |
| Molecular Weight | 362.38 |
| Flash Point | 523.6±34.3 °C |
| PSA | 144.49000 |
| LogP | -2.43 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.617 |
| Storage condition | −20°C |
| Water Solubility | H2O: 10 mg/mL, clear, colorless |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | TW3580000 |
| Precursor 9 | |
|---|---|
| DownStream 0 | |
![(2S)-2-amino-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]pentanediamide structure](https://image.chemsrc.com/caspic/323/28613-24-3.png)
