DC Chemicals Limited
China
Product Name: N-Iminoethyl-L-lysine dihydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

159190-45-1

159190-45-1 structure

159190-45-1 structure

Name: L-NIL dihydrochloride
Chemical Name: L-N6-(1-Iminoethyl)lysine dihydrochloride
CAS Number: 159190-45-1
Molecular Formula: C₈H₁₉Cl₂N₃O₂
Molecular Weight: 260.161
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-08-14 13:49:13
Modify Date: 2024-01-10 15:46:30
L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].

Name	L-N6-(1-Iminoethyl)lysine dihydrochloride
Synonyms	N(6)-acetimidoyl-L-lysine dihydrochloride N-Ethanimidoyl-L-lysine dihydrochloride l-n6-(1-iminoethyl)lysine dihydrochloride L-Lysine, N-(1-iminoethyl)-, hydrochloride (1:2)

Description	L-NIL dihydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for miNOS[1][2][3].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
Target	IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)[3].
In Vitro	L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA[2].
In Vivo	L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice[1]. Animal Model: Adult male Balb/c (20-25 g)[1]. Dosage: 10 and 30 mg/kg. Administration: Intraperitoneally at the end of CLP and at 6 h after sepsis induction. Result: Led to a negligible increase in plasma NGAL compared to sham mice. Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
References	[1]. Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316(4):F624-F634. [2]. Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635. [3]. W M Moore, et al. L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37(23):3886-8.

Boiling Point	369ºC at 760 mmHg
Molecular Formula	C₈H₁₉Cl₂N₃O₂
Molecular Weight	260.161
Flash Point	177ºC
Exact Mass	259.085419
PSA	99.20000
LogP	2.95030
Storage condition	20°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S37/39
RIDADR	NONH for all modes of transport