54143-55-4

54143-55-4 structure

Name: flecainide
Chemical Name: flecainide
CAS Number: 54143-55-4
Molecular Formula: C₁₇H₂₀F₆N₂O₃
Molecular Weight: 414.34300
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-06-03 08:00:00
Modify Date: 2024-01-05 11:47:34
Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na+ current (INa) and the rapid component of the delayed rectifier K+ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias[1][2][3].

Name	flecainide
Synonyms	N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide FLECAINTDE BASE N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide 2,5-bis-(2,2,2-Trifluoroethoxy)-n-(2-piperidyl-methyl)-benzamid EINECS 200-659-6 N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide Flecainide Benzamide,N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy) Flecanide Flecaine MFCD00864713

Description	Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na+ current (INa) and the rapid component of the delayed rectifier K+ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Echt DS, et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med. 1991 Mar 21;324(12):781-8. [2]. Aliot E, et al. Twenty-five years in the making: flecainide is safe and effective for the management of atrial fibrillation. Europace. 2011 Feb;13(2):161-73. [3]. Allan LD, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991 Jan;65(1):46-8.

22990-77-8

35480-31-0

~87%

54143-55-4

Literature: Wang, Zhi-Xian; Li, Yuanqiang; Guntoori, Bhaskar Reddy Patent: US2005/59825 A1, 2005 ; Location in patent: Page/Page column 4-5 ;