54143-55-4
54143-55-4 structure
- Name: flecainide
- Chemical Name: flecainide
- CAS Number: 54143-55-4
- Molecular Formula: C17H20F6N2O3
- Molecular Weight: 414.34300
- Catalog: API Circulatory system medication Antiarrhythmic drug
- Create Date: 2018-06-03 08:00:00
- Modify Date: 2024-01-05 11:47:34
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Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na+ current (INa) and the rapid component of the delayed rectifier K+ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias[1][2][3].
| Name | flecainide |
|---|---|
| Synonyms |
N-(2-Piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide
FLECAINTDE BASE N-(piperidin-2-ylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide 2,5-bis-(2,2,2-Trifluoroethoxy)-n-(2-piperidyl-methyl)-benzamid EINECS 200-659-6 N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzamide Flecainide Benzamide,N-(2-piperidinylmethyl)-2,5-bis(2,2,2-trifluoroethoxy) Flecanide Flecaine MFCD00864713 |
| Description | Flecainide is a potent and orally active antiarrhythmic agent. Flecainide blocks the cardiac fast inward Na+ current (INa) and the rapid component of the delayed rectifier K+ current. Flecainide prolongs the action potential duration (APD) in ventricular and atrial muscle fibres. Flecainide has the potential for the research of fetal tachycardias[1][2][3]. |
|---|---|
| Related Catalog | |
| References |
[3]. Allan LD, et al. Flecainide in the treatment of fetal tachycardias. Br Heart J. 1991 Jan;65(1):46-8. |
| Density | 1.286 g/cm3 |
|---|---|
| Boiling Point | 434.9ºC at 760 mmHg |
| Melting Point | 105-1070C |
| Molecular Formula | C17H20F6N2O3 |
| Molecular Weight | 414.34300 |
| Flash Point | 216.8ºC |
| Exact Mass | 414.13800 |
| PSA | 59.59000 |
| LogP | 4.16040 |
| Storage condition | Refrigerator |
| Symbol |
GHS02, GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H301 + H311 + H331-H370 |
| Precautionary Statements | P210-P260-P280-P301 + P310-P311 |
| Hazard Codes | F,T |
| Risk Phrases | 11-23/24/25-39/23/24/25 |
| Safety Phrases | 7-16-36/37-45 |
| RIDADR | 3249 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
|
~87%
54143-55-4 |
| Literature: Wang, Zhi-Xian; Li, Yuanqiang; Guntoori, Bhaskar Reddy Patent: US2005/59825 A1, 2005 ; Location in patent: Page/Page column 4-5 ; |
| Precursor 2 | |
|---|---|
| DownStream 1 | |
