31329-57-4

31329-57-4 structure

Name: nafronyl
Chemical Name: 2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate
CAS Number: 31329-57-4
Molecular Formula: C₂₄H₃₃NO₃
Molecular Weight: 383.52400
Catalog: API Circulatory system medication Peripheral vasodilator
Create Date: 2018-03-17 08:00:00
Modify Date: 2026-07-03 09:07:13

Name	2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate
Synonyms	3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoicacid2-(diethylamino)eth alpha-tetrahydrofurfuryl-1-naphthalenropionicacid2-(diethylamino)ethyles Praxilene Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester Tetrahydro-α-(1-naphthalenylMethyl) 2-(Diethylamino)ethyl ester tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanic acid Dubimax 2-diethylaminoethyl 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2-carboxylate 3-<Naphthyl-1->-2-<tetrahydrofuranyl-2-methyl>-propionsaeure-<3-diethylamino-ethylester> Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester 2-(Diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydro-2-furanylmethyl)propanoate Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester alpha-Tetrahydrofurfuryl-1-naphthalenropionic acid 2-(diethylamino)ethyl ester Naftidrofuryl 2-(DiethylaMino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)Methyl)propanoate Tridus Naftidrofurylum [INN-Latin] Di-Actane Nafmnyl NAFRONYL NAFRONYL //BP n-diethylaminoethylbeta-(1-naphthyl)-beta-tetrahydrofurylisobutyrate LS 84 Naphthofuramide ester 3-(1-naphthyl)-2-tetrahydrofurfurylpropionicacid2-(diethylamino)ethylester Gevatran 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate Tetrahydro-α-(1-naphtylmethyl)-2-furanpropionic acid 2-(diethylamino)ethyl ester 2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester MFCD00868290 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate EINECS 250-572-2 Dusodril 2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoicacid2-(diethylamino N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate 2-Furanpropanoic acid, tetrahydro-α-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl) Citoxid 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester Naftidrofuryl [INN:BAN] Naphtidrofuryl 3-NAPHTHALEN-1-YL-2-(TETRAHYDRO-FURAN-2-YLMETHYL)-PROPIONIC ACID 2-DIETHYLAMINO-ETHYL ESTER 2-<Tetrahydro-furfuryl>-3-<1-naphthyl>2-diaethylamino-aethylester>nafronyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionicaci2-(diethylamino)et

Density	1.079g/cm3
Boiling Point	171 °C / 4mmHg
Melting Point	80-83°C
Molecular Formula	C₂₄H₃₃NO₃
Molecular Weight	383.52400
Flash Point	267.3ºC
Exact Mass	383.24600
PSA	38.77000
LogP	4.45260

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU5800000

CHEMICAL NAME :: 2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 31329-57-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C24-H33-N-O3

MOLECULAR WEIGHT :: 383.58

WISWESSER LINE NOTATION :: L66J B1YVO2N2&2&1- BT5OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1890 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 10,291,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 272 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 8,188,1975

Hazard Codes	Xi
HS Code	2932190090

98-01-1

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

17448-96-3

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

1192-30-9

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

97-99-4

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

85068-37-7

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

37136-39-3

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

86-52-2

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

113527-39-2

77-78-1

100-37-8

31329-57-4

Literature: Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

Precursor 10
98-01-1 17448-96-3 1192-30-9 97-99-4
85068-37-7 37136-39-3 86-52-2 113527-39-2
77-78-1 100-37-8
DownStream 1
3200-06-4

HS Code	2932190090
Summary	2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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