上海阿拉丁生化科技股份有限公司
上海市上海市浦东新区
产品名：萘呋胺酯
纯度：98.0%
规格：5mg/1g/1g/1g
联系人：阿拉丁

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联系电话：400-620-6333

上海化源世纪贸易有限公司
上海市上海市普陀区
产品名：Naftidrofuryl
纯度：98.0%
规格：
联系人：小陈

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18916513247 复制
联系电话：18916513247

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31329-57-4生产厂家

31329-57-4价格

31329-57-4

31329-57-4结构式

常用中文名：萘呋胺酯
常用英文名：nafronyl
CAS号：31329-57-4
分子式：C₂₄H₃₃NO₃
分子量：383.52400
相关类别：原料药循环系统用药周围血管扩张药
发布时间：2018-03-17 08:00:00
更新时间：2026-07-03 09:07:13
【用途一】
周围血管扩张药。

化源商城直购

中文名	萘呋胺酯
英文名	2-(diethylamino)ethyl 2-(naphthalen-1-ylmethyl)-3-(oxolan-2-yl)propanoate
中文别名	萘呋胺脂 3-(1-萘基)-2-四氢糠基丙酸2-二乙氨基乙酯萘呋胺
英文别名	3-(1-Naphthyl)-2-tetrahydrofurfurylpropionic acid 2-(diethylamino)ethyl ester tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoicacid2-(diethylamino)eth alpha-tetrahydrofurfuryl-1-naphthalenropionicacid2-(diethylamino)ethyles Praxilene Tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester Tetrahydro-α-(1-naphthalenylMethyl) 2-(Diethylamino)ethyl ester tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanic acid Dubimax 2-diethylaminoethyl 1-(tetrahydro-2-furyl)-3-(1-naphthyl)propane-2-carboxylate 3-<Naphthyl-1->-2-<tetrahydrofuranyl-2-methyl>-propionsaeure-<3-diethylamino-ethylester> Tetrahydro-α-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester 2-(Diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydro-2-furanylmethyl)propanoate Tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoic acid 2-(diethylamino)ethyl ester alpha-Tetrahydrofurfuryl-1-naphthalenropionic acid 2-(diethylamino)ethyl ester Naftidrofuryl 2-(DiethylaMino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)Methyl)propanoate Tridus Naftidrofurylum [INN-Latin] Di-Actane Nafmnyl NAFRONYL NAFRONYL //BP n-diethylaminoethylbeta-(1-naphthyl)-beta-tetrahydrofurylisobutyrate LS 84 Naphthofuramide ester 3-(1-naphthyl)-2-tetrahydrofurfurylpropionicacid2-(diethylamino)ethylester Gevatran 2-(Diethylamino)ethyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate Tetrahydro-α-(1-naphtylmethyl)-2-furanpropionic acid 2-(diethylamino)ethyl ester 2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester MFCD00868290 2-(Diethylamino)ethyl 3-(naphthalen-1-yl)-2-((tetrahydrofuran-2-yl)methyl)propanoate EINECS 250-572-2 Dusodril 2-(diethylamino)ethyltetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionate tetrahydro-alpha-(1-naphthalenylmethyl)-2-furanpropanoicacid2-(diethylamino N-Diethylaminoethyl beta-(1-naphthyl)-beta-tetrahydrofuryl isobutyrate 2-Furanpropanoic acid, tetrahydro-α-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl) Citoxid 2-Furanpropanoic acid, tetrahydro-alpha-(1-naphthalenylmethyl)-, 2-(diethylamino)ethyl ester Naftidrofuryl [INN:BAN] Naphtidrofuryl 3-NAPHTHALEN-1-YL-2-(TETRAHYDRO-FURAN-2-YLMETHYL)-PROPIONIC ACID 2-DIETHYLAMINO-ETHYL ESTER 2-<Tetrahydro-furfuryl>-3-<1-naphthyl>2-diaethylamino-aethylester>nafronyl tetrahydro-alpha-(1-naphthylmethyl)-2-furanpropionicaci2-(diethylamino)et

密度	1.079g/cm3
沸点	171 °C / 4mmHg
熔点	80-83°C
分子式	C₂₄H₃₃NO₃
分子量	383.52400
闪点	267.3ºC
精确质量	383.24600
PSA	38.77000
LogP	4.45260
分子结构	1、摩尔折射率：114.22 2、摩尔体积（cm³/mol）：355.3 3、等张比容（90.2K）：910.9 4、表面张力（dyne/cm）：43.2 5、极化率（10-24cm3）：45.28
计算化学	1.疏水参数计算参考值（XlogP）:4.8 2.氢键供体数量:0 3.氢键受体数量:4 4.可旋转化学键数量:11 5.互变异构体数量:无 6.拓扑分子极性表面积38.8 7.重原子数量:28 8.表面电荷:0 9.复杂度:465 10.同位素原子数量:0 11.确定原子立构中心数量:0 12.不确定原子立构中心数量:2 13.确定化学键立构中心数量:0 14.不确定化学键立构中心数量:0 15.共价键单元数量:1
更多	1.沸点（℃,66.7Pa）190。 2.相对密度（g/mL,23/4℃）：1.0465。 3.折射率：1.5513。

毒理学数据:

急性毒性LD₅₀小鼠(mg/kg)：365口服。

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU5800000

CHEMICAL NAME :: 2-Furanpropionic acid, tetrahydro-alpha-(1-naphthylmethyl)-, 2-(diethylamino)ethyl ester

CAS REGISTRY NUMBER :: 31329-57-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C24-H33-N-O3

MOLECULAR WEIGHT :: 383.58

WISWESSER LINE NOTATION :: L66J B1YVO2N2&2&1- BT5OTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1890 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 365 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 10,291,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 129 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 272 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: GNRIDX Gendai no Rinsho. (Tokyo, Japan) V.1-10, 1967-76(?). Volume(issue)/page/year: 5,1,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 23 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9. Volume(issue)/page/year: 8,188,1975

危害码 (欧洲)	Xi
海关编码	2932190090

98-01-1

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

17448-96-3

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

1192-30-9

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

97-99-4

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

85068-37-7

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

37136-39-3

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

86-52-2

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

113527-39-2

77-78-1

100-37-8

31329-57-4

文献：Collection of Czechoslovak Chemical Communications, , vol. 52, # 10 p. 2534 - 2544

上游产品 10
98-01-1 17448-96-3 1192-30-9 97-99-4
85068-37-7 37136-39-3 86-52-2 113527-39-2
77-78-1 100-37-8
下游产品 1
3200-06-4

糠醛和丙二酸二乙酯溶于甲苯，搅拌下加入适量催化剂，回流脱水。反应液水洗，浓缩减压蒸馏，得化合物(I)，收率90%～95%(以丙二酸二乙酯计)。
化合物(I)和催化剂(Pd/C或Raney Ni)，在80～100℃和1.5～4.5MPa氢压下氢化。降温，滤除催化剂，浓缩，得化合物(Ⅱ)，产率90%～95%。
化合物(Ⅱ)和二乙氨基乙醇溶于甲苯，加入适量催化剂(如氢化钠、乙醇钠、钠或锂等碱金属化合物)，反应一定时间后，减压蒸出甲苯和过量的二乙氨基乙醇，用碱水洗，得化合物(Ⅲ)，收率85%～90%。
化合物(Ⅲ)溶于二甲基甲酰胺，剧烈搅拌下缓慢加入氢化钠，再30℃下滴加氯甲苯萘，55～60℃保温。除去二甲基甲酰胺，碱水洗，得化合物(Ⅳ)，产率75%。
化合物(Ⅳ)溶于二甲基甲酰胺，加入水回流。蒸出二甲基甲酰胺，收集198～200℃/93.3Pa的馏分，得萘呋胺，产率约85%，纯度90%。往萘呋胺的丙酮溶液中，滴加草酸水合物的丙酮溶液，加热至沸，置于冰箱。滤集沉淀，干燥，用乙醇-乙酸乙酯重结晶，得草酸萘呋胺，熔点109～110℃。

海关编码	2932190090
中文概述	2932190090 其他结构上有非稠合呋喃环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%
申报要素	品名, 成分含量, 用途
Summary	2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

1361779-23-8	137347-20-7
2411780-68-0	1021923-02-3
1333869-44-5	1042146-56-4
1227418-10-1	2304751-85-5
939803-38-0	332067-21-7

31329-57-4

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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