DC Chemicals Limited
China
Product Name: Wistin
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19046-26-5

19046-26-5 structure

19046-26-5 structure

Name: Wistin
Chemical Name: wistin
CAS Number: 19046-26-5
Molecular Formula: C₂₃H₂₄O₁₀
Molecular Weight: 460.43100
Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
Create Date: 2017-05-15 16:09:23
Modify Date: 2024-01-14 08:09:06
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist[1][2].

Name	wistin
Synonyms	AFRORMOSIN-7-GLUCOSIDE 4'',6-DIMETHOXYISOFLAVONE-7-O-B-D-GLUCOPYRANOSIDE Afromosin 7-glucoside

Description	Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR Research Areas >> Metabolic Disease
In Vitro	Wistin, is a PPARγ agonist that can induce the mRNA expression of the PPARγ target gene adiponectin in mouse 3T3-L1 cells[2]. Wistin inhibits cellular triglyceride accumulation in hepatocytes (P<0.05 at 10 μg/mL) in a dose-dependent manner[2]. Wistin (10 μg/mL) results in a 2.5-, 7.2-, and 14.8-fold increase in the expression levels of CPT1a, ACO, and ACS, respectively[2]. Treatment with Wistin for 48 h significantly decreases the amount of cellular TG in mouse primary hepatocytes in a dose-dependent manner[2]. Treatment with wistin enhanced the marker of adipocyte differentiation, such as triglyceride accumulation in 3T3-L1 cells[3]. RT-PCR[2] Cell Line: Mouse hepatocytes. Concentration: 1 or 10 μg/mL. Incubation Time: 48 h. Result: Significantly increased PPARα mRNA levels in a dose-dependent manner.
References	[1]. SeonJu Park, et al. Neuraminidase Inhibitors from the Roots of Caragana sinica. Chem Biodivers. 2020 Nov;17(11):e2000470. [2]. Misato Suzuki, et al. 4',6-Dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes. Mol Cell Biochem. 2018 Sep;446(1-2):35-41. [3]. Matoki Sanada, et al. 4',6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor γ (PPARγ) agonist that stimulates adipocyte differentiation. Anim Sci J. 2016 Nov;87(11):1347-1351.

Molecular Formula	C₂₃H₂₄O₁₀
Molecular Weight	460.43100
Exact Mass	460.13700
PSA	148.05000
LogP	0.65590