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92264-81-8

92264-81-8 structure
92264-81-8 structure
  • Name: Hydroxybupropion
  • Chemical Name: Hydroxybupropione
  • CAS Number: 92264-81-8
  • Molecular Formula: C13H18ClNO2
  • Molecular Weight: 255.74100
  • Catalog: analytical chemistry Standard standard material
  • Create Date: 2018-08-17 12:51:28
  • Modify Date: 2024-01-02 18:18:26
  • Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] .

Name Hydroxybupropione
Synonyms Hydroxybupropion
Description Hydroxybupropion is the major active metabolite of Bupropion. Hydroxybupropion is metabolized by CYP2B6.Bupropion is an atypical antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake with an IC50 value of 1.7 μM. Hydroxybupropion is also a nACh receptor antagonis tis more potent than Bupropion[1] .
Related Catalog
Target

IC50: 1.7 μM (Norepinephrine uptake)[1] nACh receptor[1]

References

[1]. Damaj MI, et al. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol. 2004 Sep;66(3):675-82.

Density 1.15 g/cm3
Boiling Point 393.9ºC at 760 mmHg
Melting Point 121-123ºC
Molecular Formula C13H18ClNO2
Molecular Weight 255.74100
Flash Point 192ºC
Exact Mass 255.10300
PSA 49.33000
LogP 2.66260
Storage condition ?20°C
Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H302 + H312 + H332-H319
Precautionary Statements P210-P261-P302 + P352 + P312-P304 + P340 + P312-P337 + P313-P403 + P235
Hazard Codes F,Xn
Risk Phrases 11-20/21/22-36
Safety Phrases 16-36/37
RIDADR UN 1648 3 / PGII
HS Code 2922509090

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Literature: SOSEI R and D LTD. Patent: WO2007/102008 A1, 2007 ; Location in patent: Page/Page column 8 ;

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Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6

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92264-81-8

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6

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92264-81-8 structure

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Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 1 p. 1 - 6
HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%