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5437-25-2

5437-25-2 structure
5437-25-2 structure
  • Name: 9H-purine-2,6-dithiol
  • Chemical Name: 2,6-Dithiopurine
  • CAS Number: 5437-25-2
  • Molecular Formula: C5H4N4S2
  • Molecular Weight: 184.24
  • Catalog: Research Areas Cancer
  • Create Date: 2018-06-01 08:00:00
  • Modify Date: 2024-01-02 17:19:22
  • 2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis[1].
Name 2,6-Dithiopurine
Synonyms MFCD00022644
9H-purine-2,6-dithiol
EINECS 226-608-8
1H-Purine-2,6-dithione, 3,9-dihydro-
2H-Purine-2-thione, 1,9-dihydro-6-mercapto-
3,7-dihydropurine-2,6-dithione
1H-purine-2,6-dithione, 3,7-dihydro-
6-Sulfanyl-1,9-dihydro-2H-purine-2-thione
3,7-Dihydro-1H-purine-2,6-dithione
Description 2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis[1].
Related Catalog
References

[1]. Stephen Boulware, et al. 2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog. Toxicol Appl Pharmacol. 2012 Sep 1;263(2):203-9.  

Density 1.8±0.1 g/cm3
Boiling Point 496.2±37.0 °C at 760 mmHg
Melting Point >350 °C(lit.)
Molecular Formula C5H4N4S2
Molecular Weight 184.24
Flash Point 253.9±26.5 °C
Exact Mass 183.987732
PSA 132.06000
LogP -0.60
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.890
Storage condition −20°C
Water Solubility slightly soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UO8475000
CHEMICAL NAME :
Purine-2,6-dithiol
CAS REGISTRY NUMBER :
5437-25-2
LAST UPDATED :
199712
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H4-N4-S2
MOLECULAR WEIGHT :
184.25
WISWESSER LINE NOTATION :
T56 BM DN FN HNJ GSH ISH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03045
Safety Phrases S24/25
WGK Germany 3
RTECS UO8475000
HS Code 2933990090
2487-40-3 structure

2487-40-3

~%

5437-25-2 structure

5437-25-2

Literature: Journal of the American Chemical Society, , vol. 76, p. 5633,5635,5636
64-18-6 structure

64-18-6

31295-41-7 structure

31295-41-7

~%

5437-25-2 structure

5437-25-2

Literature: Journal of the American Chemical Society, , vol. 76, p. 5087
98027-95-3 structure

98027-95-3

~%

5437-25-2 structure

5437-25-2

Literature: Zhurnal Obshchei Khimii, , vol. 27, p. 1712,1715;engl.Ausg.S.1783,1785
2562-52-9 structure

2562-52-9

~%

5437-25-2 structure

5437-25-2

Literature: Zhurnal Obshchei Khimii, , vol. 27, p. 1712,1715;engl.Ausg.S.1783,1785
13548-68-0 structure

13548-68-0

~%

5437-25-2 structure

5437-25-2

Literature: Zhurnal Obshchei Khimii, , vol. 27, p. 1712,1715;engl.Ausg.S.1783,1785
17356-08-0 structure

17356-08-0

5451-40-1 structure

5451-40-1

~%

5437-25-2 structure

5437-25-2

Literature: US2697709 , ;
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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