DC Chemicals Limited
China
Product Name: Clonixin
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Purity: 98.0%
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17737-65-4

17737-65-4 structure

17737-65-4 structure

Name: clonixin
Chemical Name: clonixin
CAS Number: 17737-65-4
Molecular Formula: C₁₃H₁₁ClN₂O₂
Molecular Weight: 262.692
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-02-27 08:00:00
Modify Date: 2024-01-02 18:05:58
Clonixin (SCH-10304) is an orally active analgesic and a non-steroidal anti-inflammatory agent in rodents[1].

Name	clonixin
Synonyms	2-(3-Chloro-2-methylanilino)nicotinic acid 2-[(3-chloro-2-methylphenyl)amino]pyridine-3-carboxylic acid Clonixino 2-[(3-Chloro-2-methylphenyl)amino]-3-pyridinecarboxylic acid Clonixin 2-(3-Chloro-o-toluidino)nicotinic Acid T6NJ BMR CG B1& CVQ EINECS 241-730-1 3-pyridinecarboxylic acid, 2-[(3-chloro-2-methylphenyl)amino]- Clonixic acid 2-(3-chloro-2-methylanilino)pyridine-3-carboxylic acid MFCD00864292 Deltar 2-[(3-Chloro-2-methylphenyl)amino]nicotinic acid 3-Pyridinecarboxylic acid, 2-[ (3-chloro-2-methylphenyl)amino]- Clonixinum 3-Pyridinecarboxylic acid, 2-((3-chloro-2-methylphenyl)amino)- Chlonixin Clonixine 3-Pyridinecarboxylic acid, {2-[(3-chloro-2-methylphenyl)amino]-}

Description	Clonixin (SCH-10304) is an orally active analgesic and a non-steroidal anti-inflammatory agent in rodents[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. V B Ciofalo, et al. Anti-nociceptive Activity of Clonixin in Rhesus Monkeys. Jpn J Pharmacol. 1972 Dec;22(6):749-53. [2]. J S Finch, et al. Clonixin: A Clinical Evaluation of a New Oral Analgesic. J Clin Pharmacol New Drugs. Sep-Oct 1971;11(5):371-7.

Density	1.4±0.1 g/cm3
Boiling Point	410.2±45.0 °C at 760 mmHg
Melting Point	242 °C
Molecular Formula	C₁₃H₁₁ClN₂O₂
Molecular Weight	262.692
Flash Point	201.9±28.7 °C
Exact Mass	262.050903
PSA	62.22000
LogP	5.09
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.665
Storage condition	room temp

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QT0960000

CHEMICAL NAME :: Nicotinic acid, 2-(3-chloro-o-toluidino)-

CAS REGISTRY NUMBER :: 17737-65-4

BEILSTEIN REFERENCE NO. :: 0483212

LAST UPDATED :: 199612

DATA ITEMS CITED :: 11

MOLECULAR FORMULA :: C13-H11-Cl-N2-O2

MOLECULAR WEIGHT :: 262.71

WISWESSER LINE NOTATION :: T6NTJ BMR CG B1& CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 335 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 148 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 325 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 198 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 263 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Gastrointestinal - ulceration or bleeding from stomach

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2240 mg/kg/4W-C

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Liver - changes in liver weight Blood - normocytic anemia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10920 mg/kg/26W-C

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Endocrine - changes in spleen weight Blood - normocytic anemia

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2240 mg/kg

SEX/DURATION :: male 28 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 7,655,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 280 mg/kg

SEX/DURATION :: female 9-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 9,453,1975

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 560 mg/kg

SEX/DURATION :: female 7-13 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 9,453,1975

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
HS Code	2933399090

Precursor 2
2942-59-8 87-60-5
DownStream 0

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%