Name | (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid |
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Synonyms |
Glycyrrhetyl 3-monoglucuronide
Glycyrrhetic Acid 3-O-Glucuronide 3-monoglucuronylglycyrrhetinic acid Starrhizin 3-MGA glycyrrhetic acid mono-glucuronide Glycyrrhetinic acid 3-O-mono-beta-D-glucuronide |
Description | Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener. |
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Related Catalog | |
In Vitro | Glycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β‐hexosaminidase from RBL‐2H3 cells with an IC50 value of 0.28 mM[2]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC50 value of 120 μM in LPS‐induced RAW264.7 cells[2]. |
References |
Density | 1.31g/cm3 |
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Boiling Point | 785ºC at 760mmHg |
Molecular Formula | C36H54O10 |
Molecular Weight | 646.80800 |
Flash Point | 240.7ºC |
Exact Mass | 646.37200 |
PSA | 170.82000 |
LogP | 4.32910 |
~93% 34096-83-8 |
Literature: Ruiz, Maria Carmen del Ruiz; Amer, Hassan; Stanetty, Christian; Beseda, Igor; Czollner, Laszlo; Shah, Priti; Jordis, Ulrich; Kueenburg, Bernhard; Classen-Houben, Dirk; Hofinger, Andreas; Kosma, Paul Carbohydrate Research, 2009 , vol. 344, # 9 p. 1063 - 1071 |
~93% 34096-83-8 |
Literature: Kanaoka; Yano; Kato; Nakada Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4978 - 4983 |
~% 34096-83-8 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 12 p. 4978 - 4983 |
~% 34096-83-8 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 551 - 553 |
~% 34096-83-8 |
Literature: Bioscience, biotechnology, and biochemistry, , vol. 58, # 3 p. 554 - 555 |
Precursor 6 | |
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DownStream 1 | |