34096-83-8
34096-83-8 structure
- Name: Glycyrrhetic acid 3-O-mono-beta-D-glucuronide
- Chemical Name: (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
- CAS Number: 34096-83-8
- Molecular Formula: C36H54O10
- Molecular Weight: 646.80800
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2016-08-06 04:00:45
- Modify Date: 2026-07-16 23:43:59
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Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.
| Name | (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid |
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| Synonyms |
Glycyrrhetic Acid-β-O-β-D-Glucuronide
3-monoglucuronylglycyrrhetinic acid Glycyrrhetic acid 3-O-Mono- -d-glucuronide β-D-Glucopyranosiduronic acid, (3β,20β)-20-cboxy-11-oxo-30-norolean-12-en-3-yl Glycyrrhizic Acid Impurity 21 (Glycyrrhetic acid 3-O-glucuronide) b-D-Glucopyranosiduronic acid, (3b,20b)-20-cboxy-11-oxo-30-norolean-12-en-3-yl GLYCYRRHETIC ACID 3-O-GLUCURONIDE (3β,20β)-20-Cboxy-11-oxo-30-norolean-12-en-3-yl 3-O-β-D-Glucuronopyranosyl-18β-glycyrrhetinic acid Glycyrrhetinic acid Monoglucuronide Glycyrrhetinic acid 3-O-mono-beta-D-glucuronide Glycyrrhetic Acid 3-O-Beta-D-Glucuronide 3β-(β-D-Glucurono pyranosyloxy)-11-oxooleana-12-ene-30-oic acid Starrhizin Glycyrrhetic Acid 3-O-β-D-Glucuronide 3-MGA [(18β)-20β-Cboxy-11-oxo-30-norolean-12-en-3β-yl]β-D-glucopyranosiduronic acid Glycyrrhetic acid 3-O-b-D-glucuronide Glycyrrhetyl 3-monoglucuronide Glycyrrhetic Acid Impurity 4 Glycyrrhetic acid 3-O-β-D-glucuronide, 10 mM in DMSO glycyrrhetic acid mono-glucuronide Glycyrrhetic acid 3OβDglucuronide,Glycyrrhetic acid 3 O β D glucuronide,Inhibitor,inhibit glycyrrhetyl 3-monoglucuronide Glycyrrhetic Acid 3-O-Glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide |
| Description | Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity[1]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β‐glucuronidases (β‐GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG[2].Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener. |
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| Related Catalog | |
| In Vitro | Glycyrrhetic acid 3-O-β-D-glucuronide can inhibit the release of β‐hexosaminidase from RBL‐2H3 cells with an IC50 value of 0.28 mM[2]. Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) significantly reduces the nitrite concentration in a dose-dependent manner with an IC50 value of 120 μM in LPS‐induced RAW264.7 cells[2]. |
| References |
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 785ºC at 760mmHg |
| Molecular Formula | C36H54O10 |
| Molecular Weight | 646.80800 |
| Flash Point | 240.7ºC |
| Exact Mass | 646.37200 |
| PSA | 170.82000 |
| LogP | 4.32910 |
|
~93%
34096-83-8 |
| Literature: Ruiz, Maria Carmen del Ruiz; Amer, Hassan; Stanetty, Christian; Beseda, Igor; Czollner, Laszlo; Shah, Priti; Jordis, Ulrich; Kueenburg, Bernhard; Classen-Houben, Dirk; Hofinger, Andreas; Kosma, Paul Carbohydrate Research, 2009 , vol. 344, # 9 p. 1063 - 1071 |
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~93%
34096-83-8 |
| Literature: Kanaoka; Yano; Kato; Nakada Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4978 - 4983 |
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~%
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| Literature: Chemical and Pharmaceutical Bulletin, , vol. 34, # 12 p. 4978 - 4983 |
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~%
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| Literature: Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 551 - 553 |
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| Literature: Bioscience, biotechnology, and biochemistry, , vol. 58, # 3 p. 554 - 555 |
| Precursor 6 | |
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| DownStream 1 | |