34096-83-8

• 常用中文名：单葡萄糖醛酸甘草次酸
• 常用英文名：Glycyrrhetic acid 3-O-mono-beta-D-glucuronide
• CAS号：34096-83-8
• 分子式：C₃₆H₅₄O₁₀
• 分子量：646.80800
• 相关类别： 研究领域 炎症/免疫
• 发布时间：2016-08-06 04:00:45
• 更新时间：2026-07-16 23:43:59
• Glycyrrhetic acid 3-O-β-D-glucuronide 是从甘草中分离出的甘草酸 3-O-β-D-葡萄糖醛酸,具有抗过敏活性,它是的甘草甜素 (GL) 的重要衍生物。 Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) 表明 β-葡糖醛酸糖苷酶 (β‐GUS),它的关键的 GAMG 产生酶,可以将 GL 直接转化为 GAMG。 Glycyrrhetic acid 3-O-β-D-glucuronide 可作为甜味剂。

名称

• 中文名: 甘草次酸 3-O-单-beta-D-葡糖苷酸
• 英文名: (2S,3S,4S,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• 中文别名: Glycyrrhetic acid 3-O-β-D-glucuronide #天然产物 HY-N6851; 甘草次酸 3-O-单-BETA-D-葡糖苷酸; 甘草次酸单葡萄糖醛酸苷; 单葡萄糖醛酸甘草次酸(甘草新苷); 甘草酸3-O-葡糖醛酸; 甘草新苷; 化合物：Glycyrrhetic acid 3-O-β-D-glucuronide; 单葡萄糖醛酸甘草次酸,10 MM DMSO 溶液; 化合物:Glycyrrhetic acid 3-O-β-D-glucuronide; 甘草酸杂质21(甘草次酸3-O-葡萄糖醛酸); 甘草次酸3-O-β-D-葡萄糖醛酸苷; 甘草次酸3-O-Β-D-葡糖苷酸
• 英文别名: Glycyrrhetic Acid-β-O-β-D-Glucuronide; 3-monoglucuronylglycyrrhetinic acid; Glycyrrhetic acid 3-O-Mono- -d-glucuronide; β-D-Glucopyranosiduronic acid, (3β,20β)-20-cboxy-11-oxo-30-norolean-12-en-3-yl; Glycyrrhizic Acid Impurity 21 (Glycyrrhetic acid 3-O-glucuronide); b-D-Glucopyranosiduronic acid, (3b,20b)-20-cboxy-11-oxo-30-norolean-12-en-3-yl; GLYCYRRHETIC ACID 3-O-GLUCURONIDE; (3β,20β)-20-Cboxy-11-oxo-30-norolean-12-en-3-yl; 3-O-β-D-Glucuronopyranosyl-18β-glycyrrhetinic acid; Glycyrrhetinic acid Monoglucuronide; Glycyrrhetinic acid 3-O-mono-beta-D-glucuronide; Glycyrrhetic Acid 3-O-Beta-D-Glucuronide; 3β-(β-D-Glucurono pyranosyloxy)-11-oxooleana-12-ene-30-oic acid; Starrhizin; Glycyrrhetic Acid 3-O-β-D-Glucuronide; 3-MGA; [(18β)-20β-Cboxy-11-oxo-30-norolean-12-en-3β-yl]β-D-glucopyranosiduronic acid; Glycyrrhetic acid 3-O-b-D-glucuronide; Glycyrrhetyl 3-monoglucuronide; Glycyrrhetic Acid Impurity 4; Glycyrrhetic acid 3-O-β-D-glucuronide, 10 mM in DMSO; glycyrrhetic acid mono-glucuronide; Glycyrrhetic acid 3OβDglucuronide,Glycyrrhetic acid 3 O β D glucuronide,Inhibitor,inhibit; glycyrrhetyl 3-monoglucuronide; Glycyrrhetic Acid 3-O-Glucuronide; Glycyrrhetic acid 3-O-mono-β-D-glucuronide

物化性质

• 密度: 1.31g/cm3
• 沸点: 785ºC at 760mmHg
• 分子式: C₃₆H₅₄O₁₀
• 分子量: 646.80800
• 闪点: 240.7ºC
• 精确质量: 646.37200
• PSA: 170.82000
• LogP: 4.32910
• 外观性状: 粉末
• 储存条件: 2-8°C，密封，干燥

生物活性

• 描述: Glycyrrhetic acid 3-O-β-D-glucuronide 是从甘草中分离出的甘草酸 3-O-β-D-葡萄糖醛酸,具有抗过敏活性,它是的甘草甜素 (GL) 的重要衍生物。 Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) 表明 β-葡糖醛酸糖苷酶 (β‐GUS),它的关键的 GAMG 产生酶,可以将 GL 直接转化为 GAMG。 Glycyrrhetic acid 3-O-β-D-glucuronide 可作为甜味剂。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 体外研究: 甘草次酸3-O-β-D-葡萄糖醛酸可抑制RBL-2H3细胞释放β-己糖苷酶,IC50值为0.28mm[2]。甘草次酸3-O-β-D-葡萄糖醛酸(GAMG)显著降低LPS诱导的RAW264.7细胞亚硝酸根浓度,其IC50值为120μM,呈剂量依赖性[2]。
• 参考文献:

  [1]. Park HY,et al. Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.Arch Pharm Res. 2004 Jan;27(1):57-60.

  [2]. Lichun Guo,et al. Glycyrrhetic Acid 3‐O‐Mono‐β‐d‐glucuronide (GAMG): An Innovative High‐Potency Sweetener with Improved Biological Activities. Comprehensive Reviews in Food Science and Food Safety

合成路线

1173698-23-1 ~93% 34096-83-8

文献：Ruiz, Maria Carmen del Ruiz; Amer, Hassan; Stanetty, Christian; Beseda, Igor; Czollner, Laszlo; Shah, Priti; Jordis, Ulrich; Kueenburg, Bernhard; Classen-Houben, Dirk; Hofinger, Andreas; Kosma, Paul Carbohydrate Research, 2009 , vol. 344, # 9 p. 1063 - 1071

67-56-1 27821-74-5 ~93% 34096-83-8

文献：Kanaoka; Yano; Kato; Nakada Chemical and Pharmaceutical Bulletin, 1986 , vol. 34, # 12 p. 4978 - 4983

471-53-4 ~% 34096-83-8

文献：Chemical and Pharmaceutical Bulletin, , vol. 34, # 12 p. 4978 - 4983

121709-66-8 ~% 34096-83-8

文献：Chemical and Pharmaceutical Bulletin, , vol. 37, # 2 p. 551 - 553

1477-44-7 21085-72-3 ~% 34096-83-8

文献：Bioscience, biotechnology, and biochemistry, , vol. 58, # 3 p. 554 - 555

上下游产品

上游产品  6
67-56-1 27821-74-5 471-53-4 121709-66-8
1477-44-7 21085-72-3
下游产品  1
471-53-4