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China
Product Name: (±)-Befunolol
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DC Chemicals Limited
China
Product Name: Befunolol
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Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Befunolol
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Purity: 98.0%
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39552-01-7

39552-01-7 structure

Name: (±)-Befunolol
Chemical Name: 1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
CAS Number: 39552-01-7
Molecular Formula: C₁₆H₂₁NO₄
Molecular Weight: 291.34200
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-06-17 16:22:38
Modify Date: 2024-01-03 03:20:12
(±)-Befunolol is a β-adrenoceptor blocking agent.

Name	1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
Synonyms	Befunolol HCl (±)-Befunolol

Description	(±)-Befunolol is a β-adrenoceptor blocking agent.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
Target	Adrenoreceptor[1]
In Vitro	A β-adrenoceptor blocking agent, Befunolol, is found to has intrinsic sympathomimetic activities in isolated right atria, trachea and taenia caecum of guinea pig (intrinsic activities are 0.22-0.28). The pD2-values of Befunolol estimated in the isolated organs are significantly different from its pA2-values against isoprenaline. Befunolol interacts with the beta-adrenoceptor where there may be two different sites: one site for agonistic action and the other for competitive antagonistic action. The intrinsic activity of Befunolol may be equal to its selectivity for both the sites[1].
References	[1]. Takayanagi I, et al. A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs. Gen Pharmacol. 1985;16(3):265-7.

Density	1.1049 (rough estimate)
Boiling Point	433.35°C (rough estimate)
Melting Point	115°
Molecular Formula	C₁₆H₂₁NO₄
Molecular Weight	291.34200
Exact Mass	291.14700
PSA	71.70000
LogP	2.76400
Index of Refraction	1.5500 (estimate)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB4310000

CHEMICAL NAME :: Ketone, 7-(2-hydroxy-3-(isopropylamino)propoxy)-2-benzofurany l methyl

CAS REGISTRY NUMBER :: 39552-01-7

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C16-H21-N-O4

MOLECULAR WEIGHT :: 291.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2223184

HS Code	2932999099

53943-39-8

39552-01-7

Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A

39552-12-0

75-26-3

39552-01-7

Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A

39552-17-5

39552-01-7

Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A

39552-18-6

39552-01-7

Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A

39552-00-6

75-31-0

106-89-8

39552-01-7

Literature: Kakenyaku Kako Co., Ltd. Patent: US4056626 A1, 1977 ; US 4056626 A

55636-92-5

39552-01-7

Literature: Ohara, Hirotami; Miyabe, Yoshiyuki; Deyashiki, Yoshihiro; Matsuura, Kazuya; Hara, Akira Biochemical Pharmacology, 1995 , vol. 50, # 2 p. 221 - 227

39543-77-6

75-31-0

39552-01-7

Literature: Ohishi, Yoshitaka; Nakanishi, Teruo Chemical and Pharmaceutical Bulletin, 1983 , vol. 31, # 10 p. 3418 - 3423

Precursor 10
53943-39-8 39552-12-0 75-26-3 39552-17-5
39552-18-6 39552-00-6 75-31-0 106-89-8
55636-92-5 39543-77-6
DownStream 1
55636-92-5

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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