265312-55-8

265312-55-8 structure

Name: Ryuvidine
Chemical Name: Ryuvidine,2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
CAS Number: 265312-55-8
Molecular Formula: C₁₅H₁₂N₂O₂S
Molecular Weight: 284.33300
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2016-06-02 09:13:15
Modify Date: 2024-01-27 15:45:48
Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20 in vitro[1]. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM and is cytotoxic against a range of human cancer cells[2].

Name	Ryuvidine,2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Synonyms	Ryuvidine

Description	Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20 in vitro[1]. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM and is cytotoxic against a range of human cancer cells[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK4:6.0 μM (IC50)
References	[1]. Ryu CK, et al. 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4. [2]. Blum G, et al. Small-molecule inhibitors of SETD8 with cellular activity. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.