872044-70-7
872044-70-7 structure
- Name: AN0128
- Chemical Name: 2-Pyridinecarboxylic acid, 3-hydroxy-, anhydride with B,B-bis(3-chloro-4-methylphenyl)borinic acid
- CAS Number: 872044-70-7
- Molecular Formula: C20H16BCl2NO3
- Molecular Weight: 400.06300
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2017-06-09 12:06:05
- Modify Date: 2024-01-04 00:27:25
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AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases[1][2].
| Name | 2-Pyridinecarboxylic acid, 3-hydroxy-, anhydride with B,B-bis(3-chloro-4-methylphenyl)borinic acid |
|---|---|
| Synonyms | 2-Pyridinecarboxylic acid, 3-hydroxy-, anhydride with bis(3-chloro-4-methylphenyl)borinic acid |
| Description | AN0128 is a boron-containing antibacterial and anti-inflammatory agent. AN0128 against S. aureus, S. epidermidis, P. acnes, B. subtilis with minimum inhibitory concentration (MIC) values of 1, 0.5, 0.3, 1 μg/mL. AN0128 can be used for the research of periodontal disease and cutaneous diseases[1][2]. |
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| Related Catalog | |
| In Vitro | AN0128 (compound 2g; 10 μM; 24-48 hours) shows strong inhibition of the release of pro-inflammatory cytokines (TNF-α, IL-1β) but no inhibition of IFN-γ or IL-4 release in human peripheral blood mononuclear cells (PBMCs)[1]. |
| In Vivo | AN0128 (1%, 5%; daily topical daub for 7 days) significantly reduces the formation of an inflammatory infiltrate and reduces bone loss[2]. Animal Model: Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)[2] Dosage: 1% AN0128 in 40% Transcutol P, 40% PBS, and 20% ethanol vehicle Administration: Daily topical daub for 7 days Result: Similar to Ketorolac, resulting 50% and 35% increase in bone area and bone volume respectively, and 38%, 42% decrease in bone loss and inflammation respectively. Animal Model: Experimental periodontitis in twelve-week-old male Sprague-Dawley rats (weighing from 275 to 300 g each)[2] Dosage: 5% with Total toothpaste Administration: Applied daily via a cotton-tip applicator. for 7 days Result: Had more effect than Total toothpaste, resulting in a 33% increase in bone volume, and a 47% decrease in bone loss. |
| References |
| Molecular Formula | C20H16BCl2NO3 |
|---|---|
| Molecular Weight | 400.06300 |
| Exact Mass | 399.06000 |
| PSA | 59.42000 |
| LogP | 3.67350 |