Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: HEPES
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: HEPES
Price: ￥Inquiry/25kg
Purity: 99.0%
Stocking Period: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

7365-45-9

7365-45-9 structure

Name: HEPES
Chemical Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
CAS Number: 7365-45-9
Molecular Formula: C₈H₁₈N₂O₄S
Molecular Weight: 238.305
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-10-01 19:43:14
Modify Date: 2026-06-29 18:49:06
HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].

Name	2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Synonyms	N-2-HYDROXYETHYLPIPERAZINE-N''-2-ETHANE SULPHONIC ACID N-(2-hydroxymethyl)piperazine-N｀-(2-ethanesulfonic acid)(HES) 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid(HES) N-[2-HYDROXYETHYL]PIPERAZINE-N'-[2-ETHANESULFONIC ACID];4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic Acid [Good's buffer component for biological ] N'-2-N-2-hydroxyethyl piperazineethanesulfonic acid POTASSIUM HYDROXIDE 0,5MOL/L DUTY PAID HES ULTRAPURE N-2-Hydroxyethylpiperazine-N'-2-ethanesulphonic acid, low sodium hepes solution 4-(2-Hydroxyethyl)piperazin-1-ylethansulfonsure N-(2-Hydroxyethyl)Piperazine-N'-(2-EthanesulfonicAcid)(Hes) 2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid EINECS 230-907-9 POTASSIUM HYDROXIDE 1 MOL/L DUTY PAID hes solution PHOSPHOTUNGSTIC ACID HIGH PURITY ADE 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid SELENIUM STAND 2-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]ETHANESULFONIC ACID 2-[4-(2-Hydroxyethyl)-1-piperazine]ethanesulfonic acid HES Hes,LowSodium,FreeAcid HES,BIOLOGICALBUFFER,ULTRAPURE 4-(2-hydroxyethyl)-1-piperazineethanesulfonicaci 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid HES,4-(2-hydroxyerhyl)piperazine-1-erhanesulfonic acid HES-ACID HES SynonyMs 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid HES / 4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULPHONIC ACID Hes,FreeAcid(N-[2-Hydroxyethyl]Piperaz EIT hydrobromide Hydroxyethyl)-1-piperazineethyanesulfonic acid, 4-(2 1-HtaneSulfonicAcidSod.Salt 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl) MFCD00006158 hepesfreeacid 4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID HEPES.1/2Na HES, >= (titration) LABOTEST-BB LT00138109 HES free acid, DNase, Rnase and Protease free, for moleculbiology hesfreeacid 2-[4-(2-HYDROXYETHYL)-1-PIPERAZINE]ETHANESULFONIC ACID N-(2-Hydroxyethyl)Piperazine-N'-(3-EthanesulfonicAcid) POTASSIUM HYDROXIDE 0,05 MOL DUTY PAID 2-(4-(2-Hydroxyethyl)piperazin-1-yl)ethanesulfonic acid GOOD'S BUFFER 4-CHLORO-1-NAPHTHOL ULTRA ADE HEPES,1M solution 4-(2-Hydroxyethyl)-1-Piperazin HES free acid ultrapure HES Buffer Solution (1M) LABOTEST-BB LT00233156 HES(N-[2-Hydroxyethyl]piperazine-N'-[Ethanesulfonic acid]),Free Acid HES 2-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]ETHANESULFONIC ACID N-[2-HYDROXYERHYL]PIPERAZINE-N''-ETHANESULFONICACID(HES) MALATE DEHYDROGENASE ULTRA ADE HES 2-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]ETHANESULFONIC ACID MOLECULBIOLOGY ADE 4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANESULFONIC ACID N-2-HYDROXYETHYLPIPERAZINE-N-2-ETHANSULFONICACID(HES) HES Vetec(TM) ade Hydroxyethyl)piperazine-N'-2-ethane sulfonic acid N-(2-HYDROXYETHYL)-PIPERAZINE-N'-2-ETHANESULFONIC ACID(4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID(HES-ACID)) 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid HES,BIOLOGICALBUFFER HEPES BUFFER PH 8.0 HES (4-(2-HYDROXYETHYL)PIPERAZINE-1-ETHANESULFONIC ACID) HES BUFFER HES, for biochemistry 4-(2-hydroxyerhyl)piperazine-1-erhaesulfonic acid

Description	HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Density	1.3±0.1 g/cm3
Melting Point	234-238 °C
Molecular Formula	C₈H₁₈N₂O₄S
Molecular Weight	238.305
Exact Mass	238.098724
PSA	89.46000
LogP	-2.67
Index of Refraction	1.543
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility	Soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6809000

CHEMICAL NAME :: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 7365-45-9

BEILSTEIN REFERENCE NO. :: 0883043

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H18-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9468 No. of Facilities: 239 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3025 (estimated) No. of Female Employees: 2233 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S24/25-S22-S36-S26
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	TL6809000
HS Code	29335995

HS Code	29335995

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