HEPES

Modify Date: 2025-08-21 12:35:58

HEPES structure	Common Name	HEPES
	CAS Number	7365-45-9	Molecular Weight	238.305
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₈H₁₈N₂O₄S	Melting Point	234-238 °C
	MSDS	Chinese USA	Flash Point	N/A

Use of HEPES

HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].

Name	2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Synonym	More Synonyms

Description	HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Description

HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.

[2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492.

[3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Density	1.3±0.1 g/cm3
Melting Point	234-238 °C
Molecular Formula	C₈H₁₈N₂O₄S
Molecular Weight	238.305
Exact Mass	238.098724
PSA	89.46000
LogP	-2.67
Index of Refraction	1.543
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility	Soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6809000

CHEMICAL NAME :: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 7365-45-9

BEILSTEIN REFERENCE NO. :: 0883043

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H18-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9468 No. of Facilities: 239 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3025 (estimated) No. of Female Employees: 2233 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S24/25-S22-S36-S26
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	TL6809000
HS Code	29335995

HS Code	29335995

Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.

PLoS Biol. 12(1) , e1001758, (2014)

Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of ep...

Functional consequence of the MET-T1010I polymorphism in breast cancer.

Oncotarget 6(5) , 2604-14, (2015)

Major breast cancer predisposition genes, only account for approximately 30% of high-risk breast cancer families and only explain 15% of breast cancer familial relative risk. The HGF growth factor rec...

Immunomodulation by the Pseudomonas syringae HopZ type III effector family in Arabidopsis.

PLoS ONE 9(12) , e116152, (2014)

Pseudomonas syringae employs a type III secretion system to inject 20-30 different type III effector (T3SE) proteins into plant host cells. A major role of T3SEs is to suppress plant immune responses ...

4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid

hepesfreeacid

4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid

HEPES.1/2Na

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid

EIT hydrobromide

hepes solution

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid

GOOD'S BUFFER

HEPES

HEPES BUFFER PH 8.0

2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid

EINECS 230-907-9

HEPES,1M solution

MFCD00006158

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: HEPES
Price: Check
Purity: 99.5%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: HEPES
Price: ￥718.0/500g ￥218.0/100g
Purity: 98.0%
Delivery: Inquiry
Contact: Liu jia
Email: 2130147988@qq.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: HEPES
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: HEPES
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

Get all suppliers and price by the below link:

HEPES suppliers

Price: ￥32/5g

Reference only. check more HEPES price

HEPES

Use of HEPES

Names

HEPES Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Customs

Articles4172

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.