1420-04-8

1420-04-8 structure

Name: Niclosamide olamine
Chemical Name: niclosamide-olamine
CAS Number: 1420-04-8
Molecular Formula: C₁₅H₁₅Cl₂N₃O₅
Molecular Weight: 386.230
Catalog: Signaling Pathways Autophagy Autophagy
Create Date: 2018-07-29 17:16:14
Modify Date: 2024-01-04 20:35:59
Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.

Name	niclosamide-olamine
Synonyms	Luomiecide Hl 2448 MFCD01941566 EINECS 215-811-7 Mollutox 2',5-dichloro-4'-nitrosalicylanilide 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide - 1-propanamine (1:1) Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-, compd. with 1-propanamine (1:1) clonitralid Niclosamide ethanolamine salt 2’,5-dichloro-4’-nitrosalicylanilide - 2-aminoethanol (1:1) BAYER73 (2-hydroxyethyl)ammonium 4-chloro-2-[(2-chloro-4-nitroanilino)carbonyl]phenolate BAY-73 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide—2-aminoethan-1-ol Snanilcide BAYER-6076 Clonitralide NICLOSAMIDEL 5,2'-dichloro-4'-nitro-salicylanilide ethanolamine salt 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)

Description	Niclosamide olamine is an anthelmintic that disrupts mitochondrial metabolism in parasitic worms and animal models. Niclosamide olamine inhibits STAT3 (IC50 = 0.25 μM) and stimulates autophagy by reversibly inhibiting mammalian target of Rapamycin complex 1 (mTORC1) signaling.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Autophagy >> Autophagy

Boiling Point	155-156 °C
Melting Point	91-93 °C(lit.)
Molecular Formula	C₁₅H₁₅Cl₂N₃O₅
Molecular Weight	386.230
Flash Point	149 °F
Exact Mass	385.059601
PSA	141.40000
LogP	4.09340
Stability	Stable. Hydrolyzes in concentrated acidic or basic solutions.
Water Solubility	soluble

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,103,1976/1977

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,126,1973 ** REPRODUCTIVE DATA **

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971- Volume(issue)/page/year: 53,1,1995 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989