854847-61-3

854847-61-3 structure

Name: HLY78
Chemical Name: 4-ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenantridine
CAS Number: 854847-61-3
Molecular Formula: C₁₇H₁₇NO₂
Molecular Weight: 267.32200
Catalog: Signaling Pathways Stem Cell/Wnt Wnt
Create Date: 2016-06-05 10:35:26
Modify Date: 2025-08-26 11:16:25
HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].

Name	4-ethyl-5-methyl-8,9-methylenedioxy-5,6-dihydrophenantridine
Synonyms	4-ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine 4-Aethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridin

Description	HLY78 is an activator of the Wnt/β-catenin signaling pathway, which targets the DIX domain of Axin and potentiates the Axin-LRP6 association to promote Wnt signaling transduction[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> Wnt Research Areas >> Neurological Disease
Target	Wnt/β-catenin[1]
References	[1]. Wang S, et al. Small-molecule modulation of Wnt signaling via modulating the Axin-LRP5/6 interaction. Nat Chem Biol. 2013 Sep;9(9):579-85.