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2447-57-6

2447-57-6 structure
2447-57-6 structure
  • Name: Sulfadoxine
  • Chemical Name: sulfadoxine
  • CAS Number: 2447-57-6
  • Molecular Formula: C12H14N4O4S
  • Molecular Weight: 310.329
  • Catalog: API Antibiotics Other antibiotics
  • Create Date: 2018-02-15 08:00:00
  • Modify Date: 2024-01-04 15:54:57
  • Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].

Name sulfadoxine
Synonyms sulphadoxin
4-Amino-N-(5,6-dimethoxypyrimidin-4-yl)benzolsulfonamid
Sulfadimoxine
ro4-4393
Sulphadoxine
4-amino-N-[5,6-bis(methyloxy)pyrimidin-4-yl]benzenesulfonamide
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide,Sulfadoxin
SULFADOXIN
4-Amino-N-(5,6-Dimethoxypyrimidin-4-Yl)Benzenesulfonamide
Sulfamethoxine
4-amino-N-(4',5'-dimethoxy-6'-pyrimidinyl) benzene sulphonamide
SulphodoxiMe
Sulformetoxine
4-amino-N-(5,6-diméthoxypyrimidin-4-yl)benzènesulfonamide
fanzil
wr4873
4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulphonamide
fanasil
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
Sulfadoxine
benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-
6-(4,5-dimethoxy)pyrimidinesulfanilamide
4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)- BENZENESULFONAMID
Description Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2].
Related Catalog
References

[1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html

[2]. http://en.wikipedia.org/wiki/Sulfadoxine/pyrimethamine

Density 1.4±0.1 g/cm3
Boiling Point 522.8±60.0 °C at 760 mmHg
Melting Point 190-194ºC
Molecular Formula C12H14N4O4S
Molecular Weight 310.329
Flash Point 270.0±32.9 °C
Exact Mass 310.073578
PSA 124.81000
LogP 0.34
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.623
Water Solubility Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DA9500000
CHEMICAL NAME :
Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-
CAS REGISTRY NUMBER :
2447-57-6
BEILSTEIN REFERENCE NO. :
0625453
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C12-H14-N4-O4-S
MOLECULAR WEIGHT :
310.36
WISWESSER LINE NOTATION :
T6N CNJ DO1 EO1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Vascular - BP lowering not characterized in autonomic section
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,37,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
44 gm/kg/15D-I
TOXIC EFFECTS :
Related to Chronic Data - death
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
18 gm/kg/26W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Related to Chronic Data - death
REFERENCE :
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968- Volume(issue)/page/year: 14,195,1969
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases 26
RIDADR NONH for all modes of transport
RTECS DA9500000
HS Code 2935009090
HS Code 2935009090
Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%