Name | sulfadoxine |
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Synonyms |
sulphadoxin
4-Amino-N-(5,6-dimethoxypyrimidin-4-yl)benzolsulfonamid Sulfadimoxine ro4-4393 Sulphadoxine 4-amino-N-[5,6-bis(methyloxy)pyrimidin-4-yl]benzenesulfonamide 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide,Sulfadoxin SULFADOXIN 4-Amino-N-(5,6-Dimethoxypyrimidin-4-Yl)Benzenesulfonamide Sulfamethoxine 4-amino-N-(4',5'-dimethoxy-6'-pyrimidinyl) benzene sulphonamide SulphodoxiMe Sulformetoxine 4-amino-N-(5,6-diméthoxypyrimidin-4-yl)benzènesulfonamide fanzil wr4873 4-amino-N-(5,6-dimethoxypyrimidin-4-yl)benzenesulphonamide fanasil 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide Sulfadoxine benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)- 6-(4,5-dimethoxy)pyrimidinesulfanilamide 4-AMINO-N-(5,6-DIMETHOXY-4-PYRIMIDINYL)- BENZENESULFONAMID |
Description | Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract and malarial infections.Target: AntiparasiticSulfadoxine(Sulphadoxine) is an ultra-long-lasting sulfonamide. Sulfadoxine is often used in combination with pyrimethamine to treat or prevent malaria. Both drugs are antifolates; they inhibit the production of enzymes involved in the synthesis of folic acid within the parasites. Either drug by itself is only moderately effective in treating malaria, because the parasite Plasmodium falciparum may be able to use exogenous folic acid, i.e. folic acid which is present in the parasite's environment, while in combination, the two substances have a synergistic effect which outbalances that ability [1, 2]. |
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Related Catalog | |
References |
[1]. http://www.malaria-ipca.com/sulphadoxine_pyrimethamine.html |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 522.8±60.0 °C at 760 mmHg |
Melting Point | 190-194ºC |
Molecular Formula | C12H14N4O4S |
Molecular Weight | 310.329 |
Flash Point | 270.0±32.9 °C |
Exact Mass | 310.073578 |
PSA | 124.81000 |
LogP | 0.34 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.623 |
Water Solubility | Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H315-H319-H335 |
Precautionary Statements | P305 + P351 + P338 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
Hazard Codes | Xi: Irritant; |
Risk Phrases | R36/37/38 |
Safety Phrases | 26 |
RIDADR | NONH for all modes of transport |
RTECS | DA9500000 |
HS Code | 2935009090 |
HS Code | 2935009090 |
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Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |